炎症性肠病中的生长抑素。
Somatostatin in inflammatory bowel disease.
机构信息
Department of Gastroenterology/Internal Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands.
出版信息
Mediators Inflamm. 1997;6(5-6):303-9. doi: 10.1080/09629359791424.
Abstract
Intestinal inflammation is controlled by various immunomodulating cells, interacting by molecular mediators. Neuropeptides, released by enteric nerve cells and neuroendocrine mucosa cells, are able to affect several aspects of the general and intestinal immune system, with both pro- as well as anti-inflammatory activities. In inflammatory bowel disease (IBD) there is both morphological as well as experimental evidence for involvement of neuropeptides in the pathogenesis. Somatostatin is the main inhibitory peptide in inflammatory processes, and its possible role in IBD is discussed.
摘要
肠道炎症受各种免疫调节细胞的控制，它们通过分子介质相互作用。神经肽由肠神经细胞和神经内分泌黏膜细胞释放，能够影响全身和肠道免疫系统的多个方面，具有促炎和抗炎活性。在炎症性肠病（IBD）中，形态学和实验证据均表明神经肽参与了发病机制。生长抑素是炎症过程中的主要抑制性肽，其在 IBD 中的可能作用正在讨论中。
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