Sota M, Ezpeleta C, Cisterna R
Servicio de Microbiología, Hospital de Basurto, Bilbao, Spain.
Rev Iberoam Micol. 1999 Mar;16(1):30-5.
The aim of this article is to describe the main features of fungemia belonged to the Multicenter Study Sepsis Data realised in 34 spanish hospitals. The hospitals were been given a protocol and a software specially designed for this study. 165 episodes of fungemia has been recovered (total: 5,000 episodes of bacteremia). The main results are showed as follows. Sex: male 100 (60.6%); female 65 (39.4%). Areas: medical 64 (38.8%); intensive care unit 48 (29.1%); surgical 39 (23.6%); paediatric 14 (8.5%). Underlying disease: neoplasia 43 (26.1%); HIV infection 28 (16.9%); chronic obtructive pulmonary disease 18 (10.9%); diabetes mellitus and parenteral drug abuse 15 (9.1%) every one. Nosocomial fungemia: 119 (72.1%). Community-acquired fungemia: 42 (25.5%).
primary 41 (24.9%); catheter 40 (24.2%); respiratory 23 (13.9%); urinary 17 (10.3%); abdominal 8 (4.9%); skin/soft tissues 4 (4.4%); surgical wound 6 (3.6%). Fungi most often isolated: Candida albicans, 73 isolates (44.2%); Candida parapsilosis, 20 (12.1%); Cryptococcus spp., 12 (7.3%) and Candida glabrata, 6 (3.6%). Polymicrobial fungemia: 19 (11.5%). Fluconazole (54.4%) and amphotericin B (41.9%) were the antifungal agents most often used. Mortality: 33.3%.
本文旨在描述属于在34家西班牙医院开展的多中心脓毒症数据研究中的真菌血症的主要特征。这些医院被给予了专门为此研究设计的方案和软件。已发现165例真菌血症病例（总计5000例菌血症病例）。主要结果如下。性别：男性100例（60.6%）；女性65例（39.4%）。科室：内科64例（38.8%）；重症监护病房48例（29.1%）；外科39例（23.6%）；儿科14例（8.5%）。基础疾病：肿瘤43例（26.1%）；HIV感染28例（16.9%）；慢性阻塞性肺疾病18例（10.9%）；糖尿病和静脉药物滥用各15例（9.1%）。医院获得性真菌血症：119例（72.1%）。社区获得性真菌血症：42例（25.5%）。
原发性41例（24.9%）；导管相关40例（24.2%）；呼吸道23例（13.9%）；泌尿道17例（10.3%）；腹部8例（4.9%）；皮肤/软组织4例（4.4%）；手术伤口6例（3.6%）。最常分离出的真菌：白色念珠菌，73株（44.2%）；近平滑念珠菌，20株（12.1%）；隐球菌属，12株（7.3%）；光滑念珠菌，6株（3.6%）。多微生物真菌血症：19例（11.5%）。氟康唑（54.4%）和两性霉素B（41.9%）是最常使用的抗真菌药物。死亡率：33.3%。
