van Saene H K F, Taylor N, Damjanovic V, Sarginson R E
Department of Medical Microbiology, University of Liverpool, Liverpool L69 3GA, UK.
Curr Drug Targets. 2008 May;9(5):419-21. doi: 10.2174/138945008784221189.
Polyclonality is defined as the occurrence of different genotypes of a bacterial species. We are of the opinion that these different clones originate within the patient. When infections and outbreaks occur, the terms of polyclonal infections and polyclonal outbreaks have been used, respectively. The origin of polyclonality has never been reported, although some authors suggest the acquisition of different clones from different animate and inanimate sources. We think that the gut of the critically ill patient with microbial overgrowth is the ideal site for the de-novo development of new clones, following increased spontaneous mutation.
多克隆性被定义为一个细菌物种中不同基因型的出现。我们认为这些不同的克隆源自患者体内。当感染和暴发发生时，分别使用了多克隆感染和多克隆暴发这两个术语。尽管一些作者提出从不同的有生命和无生命来源获取不同的克隆，但多克隆性的起源从未被报道过。我们认为，在微生物过度生长的危重病患者的肠道是自发突变增加后新克隆从头发育的理想场所。
