Sachse Anja, Wolf Gunter
Klinik für Innere Medizin III, University of Jena, Erlanger Allee 101, D-07347 Jena, Germany.
Curr Hypertens Rep. 2008 Apr;10(2):138-42. doi: 10.1007/s11906-008-0026-x.
Recent studies have highlighted the association between obesity and chronic renal disease. Overweight has been shown to be a survival advantage in patients on maintenance hemodialysis therapy. However, in patients with preterminal renal failure, obesity may contribute to the progression of renal disease. Data collected from the Prevention of Renal and Vascular End-stage Disease study suggest that changes in weight directly influence albuminuria, hinting that albumin excretion could be used in the general population as a surrogate marker for risk of developing chronic kidney disease. The causal pathways linking excess weight to chronic kidney disease and hypertension are briefly reviewed in this article, and therapeutic approaches to combat this growing health problem are highlighted.
近期研究突显了肥胖与慢性肾病之间的关联。超重已被证明对维持性血液透析治疗的患者具有生存优势。然而，在终末期肾衰竭前期患者中，肥胖可能会促使肾病进展。从预防肾和血管终末期疾病研究收集的数据表明，体重变化直接影响蛋白尿，这暗示在普通人群中，白蛋白排泄可作为慢性肾病发病风险的替代标志物。本文简要回顾了将超重与慢性肾病及高血压联系起来的因果途径，并着重介绍了应对这一日益严重的健康问题的治疗方法。
