Leon Lissbeth, Jeannin Jean-François, Bettaieb Ali
EPHE, Laboratoire d'immunologie et immunothérapie des cancers, Inserm U866, Dijon, F-21000, France.
Nitric Oxide. 2008 Sep;19(2):77-83. doi: 10.1016/j.niox.2008.04.014. Epub 2008 Apr 24.
Post-translational modifications of proteins can regulate the balance between survival and cell death signals. It is increasingly recognized that nitric oxide (NO) and reactive oxygen species (ROS)-induced post-translational modifications could play a role in cell death. This review provides an introduction of current knowledge of NO proteins modifications promoting or inhibiting cell death with special attention in cancer cells.
蛋白质的翻译后修饰可以调节生存信号与细胞死亡信号之间的平衡。人们越来越认识到，一氧化氮（NO）和活性氧（ROS）诱导的翻译后修饰可能在细胞死亡中发挥作用。这篇综述介绍了目前关于NO诱导的蛋白质修饰促进或抑制细胞死亡的知识，特别关注癌细胞。
