Maejima Yuko, Aoyama Masato, Ookawara Shigeo, Hirao Atsushi, Sugita Shoei
Department of Animal Science, Faculty of Agriculture, Utsunomiya University, 350 Minemachi, Utsunomiya-Shi 321-8505, Japan.
Vet J. 2009 Aug;181(2):193-9. doi: 10.1016/j.tvjl.2008.02.021. Epub 2008 May 12.
Previously it has been shown that androgen suppresses transportation-induced increases in plasma adrenocorticotropic hormone (ACTH), possibly by suppressing the secretion of corticotrophin releasing hormone (CRH) or arginine vasopressin (AVP) from the hypothalamus, or secretion of ACTH from the pituitary gland. The aim of the present study was to examine androgen target sites in the caprine diencephalon and pituitary gland using immunohistochemical methods. The androgen receptor (AR) was expressed strongly in the bed nucleus of the stria terminalis, the medial preoptic area, the arcuate nucleus, the ventromedial hypothalamic nucleus and the suprachiasmatic nucleus in the diencephalon. Between 8% and 11% of CRH and AVP neurons in the paraventricular hypothalamic nucleus (PVN) expressed AR. In the pituitary gland, 7.1% of corticotrophs expressed AR. The results are consistent with the proposal that androgen acts directly and indirectly on CRH and/or AVP neurons in the PVN. The possibility of a direct action of androgen on the corticotrophs in the pituitary gland was also considered.
先前的研究表明，雄激素可能通过抑制下丘脑促肾上腺皮质激素释放激素（CRH）或精氨酸加压素（AVP）的分泌，或垂体促肾上腺皮质激素（ACTH）的分泌，来抑制运输诱导的血浆促肾上腺皮质激素（ACTH）升高。本研究的目的是使用免疫组织化学方法检查山羊间脑和垂体中的雄激素靶位点。雄激素受体（AR）在间脑的终纹床核、内侧视前区、弓状核、腹内侧下丘脑核和视交叉上核中强烈表达。下丘脑室旁核（PVN）中8%至11%的CRH和AVP神经元表达AR。在垂体中，7.1%的促肾上腺皮质激素细胞表达AR。这些结果与雄激素直接和间接作用于PVN中的CRH和/或AVP神经元的提议一致。还考虑了雄激素对垂体中促肾上腺皮质激素细胞直接作用的可能性。
