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本文引用的文献

1
RLIP76 in defense of radiation poisoning.RLIP76对辐射中毒的防御作用。
Int J Radiat Oncol Biol Phys. 2008 Oct 1;72(2):553-61. doi: 10.1016/j.ijrobp.2008.06.1497.
2
4-Hydroxynonenal self-limits fas-mediated DISC-independent apoptosis by promoting export of Daxx from the nucleus to the cytosol and its binding to Fas.4-羟基壬烯醛通过促进Daxx从细胞核转运至细胞质并与Fas结合，从而自我限制Fas介导的非死亡诱导信号复合物依赖性凋亡。
Biochemistry. 2008 Jan 8;47(1):143-56. doi: 10.1021/bi701559f. Epub 2007 Dec 11.
3
Characterizing the role of Hsp90 in production of heat shock proteins in motor neurons reveals a suppressive effect of wild-type Hsf1.表征热休克蛋白90（Hsp90）在运动神经元中热休克蛋白产生过程中的作用，揭示了野生型热休克因子1（Hsf1）的抑制作用。
Cell Stress Chaperones. 2007 Summer;12(2):151-62. doi: 10.1379/csc-254r.1.
4
Endocytotic internalization as a crucial factor for the cytotoxicity of ribonucleases.内吞作用作为核糖核酸酶细胞毒性的关键因素。
J Biol Chem. 2007 Sep 21;282(38):27640-6. doi: 10.1074/jbc.M702240200. Epub 2007 Jul 17.
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Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis.热休克因子1和热休克蛋白70对结肠炎具有保护作用的遗传学证据。
J Biol Chem. 2007 Aug 10;282(32):23240-52. doi: 10.1074/jbc.M704081200. Epub 2007 Jun 7.
6
Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts.脂肪酸转运蛋白4是皮肤成纤维细胞中主要的极长链脂肪酰辅酶A合成酶。
J Biol Chem. 2007 Jul 13;282(28):20573-83. doi: 10.1074/jbc.M700568200. Epub 2007 May 23.
7
The non-ABC drug transporter RLIP76 (RALBP-1) plays a major role in the mechanisms of drug resistance.非ABC药物转运蛋白RLIP76（RALBP-1）在耐药机制中起主要作用。
Curr Drug Metab. 2007 May;8(4):315-23. doi: 10.2174/138920007780655414.
8
Regression of lung and colon cancer xenografts by depleting or inhibiting RLIP76 (Ral-binding protein 1).通过消耗或抑制RLIP76（Ral结合蛋白1）使肺癌和结肠癌异种移植瘤消退。
Cancer Res. 2007 May 1;67(9):4382-9. doi: 10.1158/0008-5472.CAN-06-4124.
9
Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters.连接应激信号、谷胱甘肽代谢、信号通路和外源性物质转运体。
Cancer Metastasis Rev. 2007 Mar;26(1):59-69. doi: 10.1007/s10555-007-9043-5.
10
Regulation of CD95 (Fas) expression and Fas-mediated apoptotic signaling in HLE B-3 cells by 4-hydroxynonenal.4-羟基壬烯醛对人晶状体上皮B-3细胞中CD95（Fas）表达及Fas介导的凋亡信号的调控
Biochemistry. 2006 Oct 10;45(40):12253-64. doi: 10.1021/bi060780+.

热休克因子1（Hsf-1）和POB1通过抑制Ralbp1诱导药物敏感性和细胞凋亡。

Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1.

作者信息

Singhal Sharad S, Yadav Sushma, Drake Kenneth, Singhal Jyotsana, Awasthi Sanjay

机构信息

Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107-2699, USA.

出版信息

J Biol Chem. 2008 Jul 11;283(28):19714-29. doi: 10.1074/jbc.M708703200. Epub 2008 May 12.

DOI:10.1074/jbc.M708703200
PMID:18474607
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2443664/
Abstract

Hsf-1 (heat shock factor-1) is a transcription factor that is known to regulate cellular heat shock response through its binding with the multispecific transporter protein, Ralbp1. Results of present studies demonstrate that Hsf-1 causes specific and saturable inhibition of the transport activity of Ralbp1 and that the combination of Hsf-1 and POB1 causes nearly complete inhibition through specific bindings with Ralbp1. Augmentation of cellular levels of Hsf-1 and POB1 caused dramatic apoptosis in non-small cell lung cancer cell line H358 through Ralbp1 inhibition. These findings indicate a novel model for mutual regulation of Hsf-1 and Ralbp1 through Ralbp1-mediated sequestration of Hsf-1 in the cellular cytoskeleton and Hsf-1-mediated inhibition of the transport activity of membrane-bound Ralbp1.

摘要

热休克因子1（Hsf-1）是一种转录因子，已知它通过与多特异性转运蛋白Ralbp1结合来调节细胞热休克反应。目前的研究结果表明，Hsf-1对Ralbp1的转运活性具有特异性和饱和性抑制作用，并且Hsf-1与POB1的组合通过与Ralbp1的特异性结合导致几乎完全抑制。Hsf-1和POB1细胞水平的增加通过抑制Ralbp1在非小细胞肺癌细胞系H358中引起显著凋亡。这些发现表明了一种新的模型，即通过Ralbp1介导的Hsf-1在细胞骨架中的隔离以及Hsf-1介导的对膜结合Ralbp1转运活性的抑制，实现Hsf-1和Ralbp1的相互调节。