早产、亚临床羊膜腔内感染与胎儿生物物理参数：它们之间存在关联吗？
Prematurity, subclinical intraamniotic infection, and fetal biophysical parameters: is there a correlation?
作者信息
Cox S M, Roberts S, Roussis P, Campbell B A, Curry T E
机构信息
Department of Obstetrics and Gynecology University of Kentucky Lexington, KY, USA.
出版信息
Infect Dis Obstet Gynecol. 1993;1(2):76-81. doi: 10.1155/S1064744993000183.
OBJECTIVE
This prospective study was undertaken to examine the effects of subclinical intraamniotic infection on fetal behavioral patterns.
METHODS
Amniotic fluid was obtained from four groups of patients (n = 99): group 1, patients with preterm premature rupture of the fetal membranes (PPROM) without infection; group 2, patients with PPROM and infection; group 3, patients with preterm labor (PTL) and without infection; and group 4, patients with PTL and infection. Fetal biophysical profiles were obtained on admission to the labor suite. Amniotic fluid was analyzed for the presence of microorganisms and endotoxin to confirm intraamniotic infection; cytokines interleukin (IL)-1beta, IL-6, and IL-8 were also assayed.
RESULTS
We found no association between low scores for biophysical parameters and subclinical infection in patients with PPROM or PTL.
CONCLUSIONS
We could not demonstrate that upon a patient's admission to the labor hall absent fetal breathing and absent fetal movement, as well as reactivity, correlate with subclinical intraamniotic infection. Elevated cytokines, i.e. IL-1beta, IL-6, and IL-8 were associated with subclinical chorioamnionitis.
目的
本前瞻性研究旨在探讨亚临床羊膜腔内感染对胎儿行为模式的影响。
方法
从四组患者（n = 99）获取羊水：第1组，胎膜早破早产（PPROM）且无感染的患者；第2组，PPROM且有感染的患者；第3组，早产（PTL）且无感染的患者；第4组，PTL且有感染的患者。在进入产房时获取胎儿生物物理评分。分析羊水以检测微生物和内毒素的存在，以确认羊膜腔内感染；同时检测细胞因子白细胞介素（IL）-1β、IL-6和IL-8。
结果
我们发现PPROM或PTL患者生物物理参数得分低与亚临床感染之间无关联。
结论
我们无法证明患者进入产房时胎儿呼吸缺失、胎动缺失以及反应性与亚临床羊膜腔内感染相关。细胞因子升高，即IL-1β、IL-6和IL-8与亚临床绒毛膜羊膜炎相关。
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