宫内感染与早产
Intrauterine infection and preterm labor.
作者信息
Monga M, Blanco J D
机构信息
Department of Obstetrics, Gynecology, and Reproductive Sciences University of Texas Medical School at Houston 6431 Fannin Suite 3.204, Houston, TX 77030, USA.
出版信息
Infect Dis Obstet Gynecol. 1995;3(1):37-44. doi: 10.1155/S1064744995000287.
Abstract
Preterm birth remains the leading cause of perinatal mortality and morbidity. Evidence suggests that intrauterine infection plays an important role in the pathogenesis of preterm labor. This article reviews the clinical data supporting this theory and the cellular and biochemical mechanisms by which intrauterine infection may initiate uterine contractions. The clinical and laboratory methods of diagnosing clinical chorioamnionitis and asymptomatic bacterial invasion of the intraamniotic cavity are also reviewed. Finally, the management of clinical chorioamnionitis and asymptomatic microbial invasion of the amniotic fluid and the use of adjunctive antibiotic therapy in the treatment of preterm labor are presented.
摘要
早产仍然是围产期死亡率和发病率的主要原因。有证据表明，宫内感染在早产的发病机制中起重要作用。本文综述了支持这一理论的临床数据以及宫内感染可能引发子宫收缩的细胞和生化机制。还综述了诊断临床绒毛膜羊膜炎和羊膜腔内无症状细菌入侵的临床和实验室方法。最后，介绍了临床绒毛膜羊膜炎和羊水无症状微生物入侵的管理以及辅助抗生素治疗在早产治疗中的应用。
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