花生四烯酸级联中涉及的酶的分子进化。
Molecular evolution of enzymes involved in the arachidonic acid cascade.
机构信息
Protein Engineering Research Institute 6-2-3 Furuedai Suita 565 Japan.
出版信息
Mediators Inflamm. 1992;1(4):223-33. doi: 10.1155/S0962935192000346.
The metabolic pathway called the arachidonic acid cascade produces a wide range of eicosanoids, such as prostaglandins, thromboxanes and leukotrienes with potent biological activities. Recombinant DNA techniques have made it possible to determine the nucleotide sequences of cDNAs and/or genomic structures for the enzymes involved in the pathway. Sequence comparison analyses of the accumulated sequence data have brought great insights into the structure, function and molecular evolution of the enzymes. This paper reviews the sequence comparison analyses of the enzymes involved in the arachidonic acid cascade.
被称为花生四烯酸级联的代谢途径产生了广泛的类二十烷酸，如前列腺素、血栓烷和白三烯，具有很强的生物活性。重组 DNA 技术使得确定参与该途径的酶的 cDNA 和/或基因组结构的核苷酸序列成为可能。对积累的序列数据进行的序列比较分析，使人们对这些酶的结构、功能和分子进化有了更深入的了解。本文综述了花生四烯酸级联途径中涉及的酶的序列比较分析。
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