视黄醇结合蛋白的三维结构。
The three-dimensional structure of retinol-binding protein.
作者信息
Newcomer M E, Jones T A, Aqvist J, Sundelin J, Eriksson U, Rask L, Peterson P A
出版信息
EMBO J. 1984 Jul;3(7):1451-4. doi: 10.1002/j.1460-2075.1984.tb01995.x.
Abstract
The complex of retinol with its carrier protein, retinol-binding protein (RBP) has been crystallized and its three-dimensional structure determined using X-ray crystallography. Its most striking feature is an eight-stranded up-and-down beta barrel core that completely encapsulates the retinol molecule. The retinol molecule lies along the axis of the barrel with the beta-ionone ring innermost and the tip of the isoprene tail close to the surface.
摘要
视黄醇与其载体蛋白视黄醇结合蛋白（RBP）的复合物已被结晶，并利用X射线晶体学确定了其三维结构。其最显著的特征是一个由八条链组成的上下β桶状核心，它完全包裹着视黄醇分子。视黄醇分子沿着桶的轴排列，β-紫罗兰酮环在最里面，异戊二烯尾巴的末端靠近表面。
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