艾滋病单核细胞在体外接触马红球菌后，干扰素-γ和肿瘤坏死因子-α产生缺陷。
Defective production of interferon-gamma and tumour necrosis factor-alpha by AIDS mononuclear cells after in vitro exposure to Rhodococcus equi.
机构信息
Department of Infectious and Tropical Diseases La Sapienza University Rome Italy.
出版信息
Mediators Inflamm. 1995;4(4):306-9. doi: 10.1155/S0962935195000494.
Abstract
The production of interferon-gamma and tumour necrosis factor-alpha was evaluated in the peripheral blood mononuclear cells (PBMCs) from healthy donors and AIDS patients after Rhodococcus equi infection in vitro. PBMCs from healthy donors secreted elevated levels of IFN-gamma and TNF-alpha when challenged in vitro with killed R. equi, whereas the release of both cytokines was impaired in supernatant cultures from AIDS patients. We conclude that the failure of IFN-gamma generation in AIDS patients in response to R. equi is not antigen-specific but it may reflect the global impairment of T-cell function. In such patients, however, the infection with R. equi, a facultative intracellular pathogen which survives and replicates within macrophages, may be responsible for the impairment in the TNF-alpha release, possibly enhancing the HIV-induced macrophage dysftmction.
摘要
体外检测了罗得西亚放线菌感染后健康供体和 AIDS 患者外周血单个核细胞（PBMC）中干扰素-γ和肿瘤坏死因子-α的产生。当用灭活的罗得西亚放线菌刺激时，健康供体的 PBMC 会分泌高水平的 IFN-γ和 TNF-α，而 AIDS 患者上清液培养物中这两种细胞因子的释放均受到损害。我们得出结论，AIDS 患者对罗得西亚放线菌的 IFN-γ生成失败不是抗原特异性的，但它可能反映了 T 细胞功能的全面受损。然而，在这些患者中，罗得西亚放线菌感染可能是导致 TNF-α释放受损的原因，这种机会性细胞内病原体在巨噬细胞内生存和复制，可能会增强 HIV 诱导的巨噬细胞功能障碍。
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