Center of Pharmaceutical Chemistry Department of Pharmacology and Toxicology Havana City POB 6990 Cuba.
Mediators Inflamm. 1995;4(5):364-7. doi: 10.1155/S0962935195000597.
Lobenzarit disodtulIl (CCA) is a novel immunomodulatory drug useful in the treatment of chronic inflammations. Its principal mechanism of action seems to be through enhancing the T suppressor/T helper lymphocyte ratio. However, the molecular basis for these actions remains unclear. In this study it was found that CCA inhibits the production of guanosine 3',5'-cyclic monophosphate almost completely when present in concentrations of 1 mM. Further results demonstrated that such inhibition could also be explained by interference in constitutive nitric oxide generation. In addition to previous findings, more insight into the molecular mechanism of action of CCA is provided.
洛贝沙替丁二钠(CCA)是一种新型的免疫调节药物,可用于治疗慢性炎症。其主要作用机制似乎是通过增强 T 抑制/T 辅助淋巴细胞比值。然而,这些作用的分子基础尚不清楚。本研究发现,当浓度为 1mM 时,CCA 几乎完全抑制鸟苷 3',5'-环单磷酸的产生。进一步的结果表明,这种抑制也可以通过干扰固有一氧化氮的产生来解释。除了以前的发现外,本研究还进一步深入了解了 CCA 的作用机制。