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洛贝林二钠抑制组成型 NO-cGMP 代谢途径。可能作为免疫调节药物参与其中。

Lobenzarit disodium inhibits the constitutive NO-cGMP metabolic pathways. Possible involvement as an immunomodulatory drug.

机构信息

Center of Pharmaceutical Chemistry Department of Pharmacology and Toxicology Havana City POB 6990 Cuba.

出版信息

Mediators Inflamm. 1995;4(5):364-7. doi: 10.1155/S0962935195000597.

DOI:10.1155/S0962935195000597
PMID:18475666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2365655/
Abstract

Lobenzarit disodtulIl (CCA) is a novel immunomodulatory drug useful in the treatment of chronic inflammations. Its principal mechanism of action seems to be through enhancing the T suppressor/T helper lymphocyte ratio. However, the molecular basis for these actions remains unclear. In this study it was found that CCA inhibits the production of guanosine 3',5'-cyclic monophosphate almost completely when present in concentrations of 1 mM. Further results demonstrated that such inhibition could also be explained by interference in constitutive nitric oxide generation. In addition to previous findings, more insight into the molecular mechanism of action of CCA is provided.

摘要

洛贝沙替丁二钠（CCA）是一种新型的免疫调节药物，可用于治疗慢性炎症。其主要作用机制似乎是通过增强 T 抑制/T 辅助淋巴细胞比值。然而，这些作用的分子基础尚不清楚。本研究发现，当浓度为 1mM 时，CCA 几乎完全抑制鸟苷 3'，5'-环单磷酸的产生。进一步的结果表明，这种抑制也可以通过干扰固有一氧化氮的产生来解释。除了以前的发现外，本研究还进一步深入了解了 CCA 的作用机制。

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本文引用的文献

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Chlorpromazine inhibits both the constitutive nitric oxide synthase and the induction of nitric oxide synthase after LPS challenge.氯丙嗪可抑制组成型一氧化氮合酶以及脂多糖刺激后一氧化氮合酶的诱导。
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Evidence for the inhibitory role of guanosine 3', 5'-monophosphate in ADP-induced human platelet aggregation in the presence of nitric oxide and related vasodilators.在一氧化氮及相关血管舒张剂存在的情况下，鸟苷3',5'-单磷酸对二磷酸腺苷诱导的人血小板聚集的抑制作用的证据。
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Guanosine 3':5'-cyclic monophosphate: a possible intracellular mediator of mitogenic influences in lymphocytes.3':5'-环磷酸鸟苷：淋巴细胞有丝分裂影响的一种可能的细胞内介质。
Proc Natl Acad Sci U S A. 1972 Oct;69(10):3024-7. doi: 10.1073/pnas.69.10.3024.
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Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.中枢神经系统中由L-精氨酸生成一氧化氮：一种刺激可溶性鸟苷酸环化酶的转导机制。
Proc Natl Acad Sci U S A. 1989 Jul;86(13):5159-62. doi: 10.1073/pnas.86.13.5159.
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Inhibition of chemotaxis Ng-monomethyl-L-arginine: a role for cyclic GMP.
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Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands.来自L-精氨酸的一氧化氮刺激肾上腺中的可溶性鸟苷酸环化酶。
Biochem Biophys Res Commun. 1989 Dec 15;165(2):802-9. doi: 10.1016/s0006-291x(89)80037-3.
10
Anti-oxidative profile of lobenzarit disodium (CCA).
Biochem Pharmacol. 1990 Nov 1;40(9):2117-22. doi: 10.1016/0006-2952(90)90243-e.

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