Palacios M, Padron J, Glaria L, Rojas A, Delgado R, Knowles R, Moncada S
Pharmacology and Toxicology Dept., Center of Pharmaceutical Chemistry, Havana, Cuba.
Biochem Biophys Res Commun. 1993 Oct 15;196(1):280-6. doi: 10.1006/bbrc.1993.2246.
The effects of chlorpromazine on either the activity of mouse brain nitric oxide synthase or the induction of lung nitric oxide synthase in mice and rats were studied. Chlorpromazine inhibited the nitric oxide synthase activity in mouse brain cytosol. This effect could be reversed by adding an excess of calmodulin. In addition, chlorpromazine was able to inhibit the induction of lung nitric oxide synthase, in both species, after LPS administration. Furthermore, chlorpromazine also inhibited arginase activity in mouse lung cytosol.
研究了氯丙嗪对小鼠脑一氧化氮合酶活性以及对小鼠和大鼠肺一氧化氮合酶诱导的影响。氯丙嗪抑制小鼠脑细胞质中的一氧化氮合酶活性。添加过量的钙调蛋白可逆转此效应。此外，氯丙嗪能够抑制脂多糖给药后两种动物肺一氧化氮合酶的诱导。此外，氯丙嗪还抑制小鼠肺细胞质中的精氨酸酶活性。
