来自L-精氨酸的一氧化氮刺激肾上腺中的可溶性鸟苷酸环化酶。
Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands.
作者信息
Palacios M, Knowles R G, Palmer R M, Moncada S
机构信息
Wellcome Research Laboratories, Beckenham, Kent, U.K.
出版信息
Biochem Biophys Res Commun. 1989 Dec 15;165(2):802-9. doi: 10.1016/s0006-291x(89)80037-3.
The formation of nitric oxide (NO) by an L-arginine:NO synthase and its stimulation of the soluble guanylate cyclase was studied in rat whole adrenal and bovine cortex and medulla cytosol. In the presence of L-arginine, the stimulation of soluble guanylate cyclase was accompanied by the formation of citrulline and NO2-, formed from NO. The NO synthase was NADPH- and Ca(2+)-dependent and was inhibited by several L-arginine analogues. These results indicate that rat and bovine adrenal cytosol contains an L-arginine:NO synthase.
在大鼠全肾上腺以及牛肾上腺皮质和髓质细胞溶胶中，研究了由L-精氨酸：一氧化氮合酶生成一氧化氮（NO）及其对可溶性鸟苷酸环化酶的刺激作用。在L-精氨酸存在的情况下，可溶性鸟苷酸环化酶的刺激伴随着瓜氨酸和由NO生成的NO2-的形成。一氧化氮合酶依赖于NADPH和Ca(2+)，并被几种L-精氨酸类似物抑制。这些结果表明，大鼠和牛肾上腺细胞溶胶中含有L-精氨酸：一氧化氮合酶。
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