曲古霉素与克林霉素联合氨曲南治疗非社区获得性妇产科感染的双盲、多中心、前瞻性随机研究
Double-blind, multicenter, prospective randomized study of trospectomycin vs. Clindamycin, both with aztreonam, in non-community acquired obstetric and gynecologic infections.
作者信息
Chatwani A, Martens M, Blanco J, Gall S, Przybylko K, Wajszczuk C P, Nickens D
机构信息
Department of Obstetrics and Gynecology Temple University School of Medicine Philadelphia PA USA.
出版信息
Infect Dis Obstet Gynecol. 1997;5(4):280-5. doi: 10.1155/S1064744997000483.
OBJECTIVE
The purpose of this study was to compare the clinical efficacy and safety of trospectomycin sulfate with that of clindamycin phosphate, both with aztreonam, for the treatment of obstetric and gynecologic infections.
METHODS
In a double-blind, multicenter, prospective randomized study, 579 patients with either endometritis following cesarean delivery or pelvic cellulitis following hysterectomy were enrolled and received medication. Administered was either trospectomycin sulfate 500 mg IV every 8 h or clindamycin phosphate 900 mg IV every 8 h in a 1:1 randomization ratio. Both groups of patients received aztreonam 1 g IV every 8 h. The patients were followed for clinical responses and side effects.
RESULTS
The cure rate for the trospectomycin sulfate arm was 91.8% and for clindamycin phosphate arm it was 88.4% (P = 0.218). The adverse events were similar in both groups.
CONCLUSIONS
Trospectomycin was as effective as clindamycin, when both were combined with aztreonam, in treatment of obstetric and gynecologic infections.
目的
本研究旨在比较硫酸壮观霉素与磷酸克林霉素联合氨曲南治疗妇产科感染的临床疗效和安全性。
方法
在一项双盲、多中心、前瞻性随机研究中，纳入579例剖宫产术后子宫内膜炎或子宫切除术后盆腔蜂窝织炎患者并给予药物治疗。按1:1随机比例，每8小时静脉注射500mg硫酸壮观霉素或每8小时静脉注射900mg磷酸克林霉素。两组患者均每8小时静脉注射1g氨曲南。对患者进行临床反应和副作用随访。
结果
硫酸壮观霉素组的治愈率为91.8%，磷酸克林霉素组为88.4%（P = 0.218）。两组的不良事件相似。
结论
硫酸壮观霉素和磷酸克林霉素联合氨曲南治疗妇产科感染时疗效相当。
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