Pastorek J G, Cole C, Aldridge K E, Crapanzano J C
Am J Med. 1985 Feb 8;78(2A):47-50. doi: 10.1016/0002-9343(85)90204-9.
Aztreonam, a new monobactam antibiotic with specific gram-negative aerobic activity, was used in combination with clindamycin in the treatment of 40 women with pelvic infection, including post-partum endometritis, pelvic inflammatory disease, and post-hysterectomy pelvic cellulitis. Clinical cure was achieved in 87 percent of patients. Failure was related to the limited gram-positive aerobic spectrum of clindamycin. All aerobic gram-negative enteric organisms were sensitive in vitro to less than 0.125 microgram/ml of aztreonam.
氨曲南是一种具有特定革兰氏阴性需氧菌活性的新型单环β-内酰胺类抗生素，它与克林霉素联合用于治疗40例患有盆腔感染的女性，包括产后子宫内膜炎、盆腔炎和子宫切除术后盆腔蜂窝织炎。87%的患者实现了临床治愈。治疗失败与克林霉素有限的革兰氏阳性需氧菌谱有关。所有需氧革兰氏阴性肠道菌在体外对低于0.125微克/毫升的氨曲南敏感。
