Kiss T, Lázár I, Kafarski P
Department of Inorganic and Analytical Chemistry Kossuth Lajos University P.O. Box 21 Debrecen H -4010 Hungary.
Met Based Drugs. 1994;1(2-3):247-64. doi: 10.1155/MBD.1994.247.
The metal-binding abilities of a wide variety of bioactive aminophosphonates, from the simple aminoethanephosphonic acids to the rather large macrocyclic polyaza derivatives, are discussed with special emphasis on a comparison of the analogous carboxylic acid and phosphonic acid systems. Examples are given of the biological importance of metal ion - aminophosphonate interactions in living systems, and also of their actual and potential applicability in medicine.
本文讨论了多种生物活性氨基膦酸酯（从简单的氨基乙烷膦酸到相当大的大环多氮杂衍生物）的金属结合能力，特别强调了对类似羧酸和膦酸体系的比较。文中给出了金属离子 - 氨基膦酸酯相互作用在生物系统中的生物学重要性的实例，以及它们在医学中的实际和潜在应用。
