人结肠直肠癌和黏膜中的环磷酸腺苷结合蛋白
Cyclic adenosine 3',5'-monophosphate binding proteins in human colorectal cancer and mucosa.
作者信息
Bradbury A W, Miller W R, Carter D C
机构信息
University Department of Clinical Surgery, Royal Infirmary, Edinburgh, UK.
出版信息
Br J Cancer. 1991 Feb;63(2):201-4. doi: 10.1038/bjc.1991.49.
Cyclic AMP Binding Proteins (cAMP-BP) levels have been measured by means of a competitive binding assay in the cytosols of 50 human colorectal cancers. These levels have been related to those in mucosa both adjacent to and distant from the tumour in the same patients. Cyclic AMP-BP were higher in tumour than in either adjacent (P less than 0.000001) or distant mucosa (P less than 0.00001). Binding of cAMP in adjacent mucosa was lower than that in distant mucosa (P less than 0.0001). There was no significant difference in the level of binding between tumours arising from different sites in the colon and binding was not related to age or sex of the patient. However, binding was higher in Dukes' B than Dukes' C cancers (P less than 0.005). There was also a trend for cAMP binding levels to be higher in moderately differentiated than in poorly differentiated cancers (P = 0.07). Thus cAMP-BP appear to be over-expressed in human colorectal cancers and levels are related to the stage and grade.
已通过竞争性结合测定法测量了50例人类结直肠癌胞质溶胶中的环磷酸腺苷结合蛋白（cAMP-BP）水平。这些水平与同一患者肿瘤附近和远处黏膜中的水平相关。肿瘤中的环磷酸腺苷结合蛋白水平高于相邻黏膜（P<0.000001）或远处黏膜（P<0.00001）。相邻黏膜中环磷酸腺苷的结合低于远处黏膜（P<0.0001）。结肠不同部位产生的肿瘤之间的结合水平无显著差异，且结合与患者年龄或性别无关。然而，Dukes' B期癌症的结合高于Dukes' C期癌症（P<0.005）。中等分化癌症的环磷酸腺苷结合水平也有高于低分化癌症的趋势（P = 0.07）。因此，环磷酸腺苷结合蛋白似乎在人类结直肠癌中过度表达，且水平与分期和分级相关。
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