Bedikian Agop Y, Del Vecchio Michele
The University of Texas MD Anderson Cancer Center, Department of Melanoma Medical Oncology, 1515 Holcombe Blvd, Box 430, Houston, TX 77030, USA.
Expert Opin Biol Ther. 2008 Jun;8(6):839-44. doi: 10.1517/14712598.8.6.839.
Patients with metastatic melanoma are immunosuppressed by the growing tumor. Allovectin-7 therapy is a form of active immunotherapy that aims at immunization of the host with substances designed to elicit an immune reaction that will eliminate or slow down the growth and spread of the cancer.
to describe the rationale for immunotherapy with Allovectin-7 and assess its safety profile and efficacy based on the results of completed melanoma clinical trials.
we reviewed both the published medical literature and the results of trials pending publication.
RESULTS/CONCLUSION: Allovectin-7 is a safe and active immunotherapeutic agent. It induces local and systemic durable responses in patients with metastatic melanoma.
转移性黑色素瘤患者会因不断生长的肿瘤而出现免疫抑制。Allovectin-7疗法是一种主动免疫疗法，旨在用旨在引发免疫反应的物质对宿主进行免疫，这种免疫反应将消除或减缓癌症的生长和扩散。
描述Allovectin-7免疫疗法的基本原理，并根据已完成的黑色素瘤临床试验结果评估其安全性和疗效。
我们查阅了已发表的医学文献以及尚未发表的试验结果。
结果/结论：Allovectin-7是一种安全有效的免疫治疗药物。它能在转移性黑色素瘤患者中诱导局部和全身的持久反应。
