化疗在黑色素瘤现代治疗中的作用。
The role for chemotherapy in the modern management of melanoma.
作者信息
Gupta Avinash, Gomes Fabio, Lorigan Paul
机构信息
Department of Medical Oncology, The Christie NHS Foundation Trust, Manchester, M20 4BX, UK.
Division of Molecular & Clinical Cancer Sciences, University of Manchester, Manchester, M13 9PL, UK.
出版信息
Melanoma Manag. 2017 May;4(2):125-136. doi: 10.2217/mmt-2017-0003. Epub 2017 May 19.
Abstract
The treatment of malignant melanoma has changed beyond recognition in the last 7 years. Where previously single agent dacarbazine was often the only treatment used for advanced disease, now there are potentially multiple lines of treatment, based on immunotherapy and targeted treatment options, either as monotherapy or in combination. In this brave new world the question arises, does chemotherapy still have any relevance in the modern management of melanoma? In this review, we summarize the various chemotherapeutic options that have been trialled in melanoma to date, and discuss the role chemotherapy may still play in treating melanoma, potentially in combination with more novel agents, or in certain subtypes of melanoma.
摘要
在过去7年里，恶性黑色素瘤的治疗发生了翻天覆地的变化。以前，对于晚期疾病，通常仅使用单药达卡巴嗪进行治疗，而如今，基于免疫疗法和靶向治疗方案，无论是单药治疗还是联合治疗，都有多种潜在的治疗方案。在这个全新的领域中，问题随之而来：化疗在黑色素瘤的现代治疗中是否仍有意义？在这篇综述中，我们总结了迄今为止在黑色素瘤中试验过的各种化疗方案，并讨论了化疗在治疗黑色素瘤中可能仍发挥的作用，可能与更新颖的药物联合使用，或在某些黑色素瘤亚型中使用。
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