Collin H B, Abelson M B
Arch Ophthalmol. 1976 Oct;94(10):1726-9. doi: 10.1001/archopht.1976.03910040500007.
A case of recurrent herpes simplex virus keratouveitis was studied using both electron microscopic and viral culture techniques. We describe a patient who had a particularly violent course, including three failed grafts, endophthalmitis, and wound leak. We report the identification of virus in a quiescent failed corneal graft and retrocorneal membrane; persistence of virus enabling its culture from the vitreous; and electron microscopic identification in the cornea removed at the third transplant. The identification of cases in which viral proliferation occurs is necessary for a greater understanding of the pathogenesis of herpetic corneal disease and for determining in which particular patient steroid therapy should be avoided.
采用电子显微镜和病毒培养技术对一例复发性单纯疱疹病毒性角膜葡萄膜炎病例进行了研究。我们描述了一位病情特别严重的患者，包括三次移植失败、眼内炎和伤口渗漏。我们报告了在静止的失败角膜移植片和角膜后弹力层中发现病毒；病毒的持续存在使其能从玻璃体中培养出来；以及在第三次移植时摘除的角膜中通过电子显微镜鉴定出病毒。确定发生病毒增殖的病例对于更深入了解疱疹性角膜疾病的发病机制以及确定哪些特定患者应避免使用类固醇疗法是必要的。
