Lançoni Glalcyara, Ravinal Roberto Cuan, Costa Roberto Silva, Roselino Ana Maria
Division of Dermatology, Department of Medical Clinic, School of Medicine of Ribeirão Preto, University of São Paulo, São Paulo, Brazil.
Int J Dermatol. 2008 Jun;47(6):575-81. doi: 10.1111/j.1365-4632.2008.03607.x.
Porphyria cutanea tarda (PCT) is a metabolic disease characterized by vesicles and blisters in sun-exposed areas and scleroderma-like lesions in sun-exposed and non-sun-exposed areas. Mast cells participate in the pathogenesis of bullous diseases and diseases that show sclerosis, including PCT. Moreover, transforming growth factor-beta (TGF-beta) is the main cytokine in the development of tissue sclerosis. The correlation of mast cells and TGF-beta with the lesions of PCT has not been examined, however. The possible role of mast cells and TGF-beta (and the relationship between them) in the development of PCT lesions is discussed.
To quantify mast cells and cells expressing TGF-beta in skin samples from patients with PCT and controls, immunohistochemical studies were performed in tissue sections allied to morphometric analyses.
The numbers of mast cells and cells expressing TGF-beta per square millimeter were increased in the PCT group relative to controls, and there was a direct and significant correlation between the mast cell number and cells expressing TGF-beta in PCT.
The results suggest that the increased number of mast cells and of cells expressing TGF-beta, as well as their direct correlation, may contribute to the pathogenesis of the skin lesions in PCT.
迟发性皮肤卟啉症（PCT）是一种代谢性疾病，其特征为暴露于阳光下的部位出现水疱和大疱，以及暴露和非暴露部位出现硬皮病样病变。肥大细胞参与大疱性疾病和表现为硬化的疾病（包括PCT）的发病机制。此外，转化生长因子-β（TGF-β）是组织硬化发展过程中的主要细胞因子。然而，肥大细胞和TGF-β与PCT病变的相关性尚未得到研究。本文讨论了肥大细胞和TGF-β在PCT病变发展中的可能作用（以及它们之间的关系）。
为了量化PCT患者和对照组皮肤样本中的肥大细胞和表达TGF-β的细胞，在与形态计量分析相关的组织切片中进行了免疫组织化学研究。
与对照组相比，PCT组每平方毫米的肥大细胞和表达TGF-β的细胞数量增加，并且在PCT中肥大细胞数量与表达TGF-β的细胞之间存在直接且显著的相关性。
结果表明，肥大细胞和表达TGF-β的细胞数量增加以及它们之间的直接相关性可能有助于PCT皮肤病变的发病机制。
