Gonzales G F, Gasco M, Malheiros-Pereira A, Gonzales-Castañeda C
Faculty of Sciences and Philosophy, Instituto de Investigaciones de la Altura, Universidad Peruana Cayetano Heredia, Lima, Peru.
Andrologia. 2008 Jun;40(3):179-85. doi: 10.1111/j.1439-0272.2008.00834.x.
The plants from the Lepidium gender have demonstrated to have effect on the size of the prostate. Lepidium meyenii (Maca) is a Peruvian plant that grows exclusively over 4000 m above sea level. The present study was designed to determine the effect of red maca (RM) in the prostate hyperplasia induced with testosterone enanthate (TE) in adult mice. Prostate hyperplasia was induced by administering TE, and then these animals (n = 6, each group) were treated with RM or Finasteride (positive control) for 21 days. There was an additional group without prostate hyperplasia (vehicle). Mice were killed on days 7, 14 and 21 after treatment with RM. Testosterone and oestradiol levels were measured on the last day of treatment. Prostatic stroma, epithelium and acini were measured histologically. RM reduced prostate weight at 21 days of treatment. Weights of seminal vesicles, testis and epididymis were not affected by RM treatment. The reduction in prostate size by RM was 1.59 times. Histological analysis showed that TE increased 2-fold the acinar area, effect prevented in the groups receiving TE + RM for 14 (P < 0.05) and 21 (P < 0.05) days and the group receiving TE + Finasteride for 21 days (P < 0.05). TE increased prostatic stroma area and this effect was prevented by treatment with RM since 7 days of treatment or Finasteride. The reduction in prostatic stroma area by RM was 1.42 times. RM has an anti-hyperplastic effect on the prostate of adult mice when hyperplasia was induced with TE acting first at prostatic stromal level.
独行菜属植物已被证明对前列腺大小有影响。玛卡（Lepidium meyenii）是一种仅生长在海拔4000米以上的秘鲁植物。本研究旨在确定红玛卡（RM）对成年小鼠中由庚酸睾酮（TE）诱导的前列腺增生的影响。通过给予TE诱导前列腺增生，然后将这些动物（每组n = 6）用RM或非那雄胺（阳性对照）治疗21天。还有一组没有前列腺增生（赋形剂组）。在用RM治疗后的第7、14和21天处死小鼠。在治疗的最后一天测量睾酮和雌二醇水平。对前列腺基质、上皮和腺泡进行组织学测量。RM在治疗21天时降低了前列腺重量。精囊、睾丸和附睾的重量不受RM治疗的影响。RM使前列腺大小缩小了1.59倍。组织学分析表明，TE使腺泡面积增加了2倍，在接受TE + RM治疗14天（P < 0.05）和21天（P < 0.05）的组以及接受TE +非那雄胺治疗21天的组（P < 0.05）中，这种作用得到了预防。TE增加了前列腺基质面积，自治疗7天起用RM或非那雄胺治疗可预防这种作用。RM使前列腺基质面积缩小了1.42倍。当用TE诱导成年小鼠前列腺增生时，RM首先在前列腺基质水平起作用，对前列腺具有抗增生作用。
