两种不同红玛咖提取物对睾酮诱导的前列腺增生雄性大鼠的影响。

Effect of two different extracts of red maca in male rats with testosterone-induced prostatic hyperplasia.

作者信息

Gonzales Gustavo F, Vasquez Vanessa, Rodriguez Daniella, Maldonado Carmen, Mormontoy Juliet, Portella Jimmy, Pajuelo Monica, Villegas León, Gasco Manuel

机构信息

Biological and Physiological Sciences, Cayetano Heredia University, Lima, Peru.

出版信息

Asian J Androl. 2007 Mar;9(2):245-51. doi: 10.1111/j.1745-7262.2007.00228.x.

DOI:10.1111/j.1745-7262.2007.00228.x

PMID:17334591

Abstract

AIM

To determine the effect of two different extracts of red maca in male rats.

METHODS

Prostatic hyperplasia was induced in male rats with testosterone enanthate (TE). The study comprised six groups: one control group (group 1), one group treated with TE (group 2), two groups treated with TE and aqueous extract of red maca (groups 3 and 4), one group treated with hydroalcoholic extract of red maca (group 5) and one group treated with finasteride (0.1 mg, group 6). Differences in the aqueous extract dependent on the length of time of boiling, whether for 2 or 3 hours, for groups 3 and 4 was assessed. Extracts of red maca contained 0.1 mg of benzylglucosinolate. Thereafter, a dose-response effect of different doses of benzylglucosinolates (0.02-0.08 mg) in red maca extracts was assessed.

RESULTS

Prostate weight was similar in rats treated with freeze-dried aqueous extract of red maca prepared after 2 and 3 hours of boiling. Freeze-dried aqueous extract of red maca, hydroalcoholic extract of red maca and finasteride reduced prostate weight in rats with prostatic hyperplasia. No difference was observed between the data obtained from aqueous extract or hydroalcoholic extract of red maca. A dose dependent reduction of prostate weight was observed with the increase of the dose of benzylglucosinolates in red maca extracts.

CONCLUSION

The present study showed that hydroalcoholic or aqueous extract of red maca containing 0.1 mg of benzylglucosinolate can reduce prostate size in male rats in which prostatic hyperplasia had been induced by TE.

摘要

目的

确定两种不同的红玛咖提取物对雄性大鼠的影响。

方法

用庚酸睾酮（TE）诱导雄性大鼠前列腺增生。该研究包括六组：一组对照组（第1组），一组用TE治疗（第2组），两组用TE和红玛咖水提取物治疗（第3组和第4组），一组用红玛咖醇水提取物治疗（第5组），一组用非那雄胺治疗（0.1毫克，第6组）。评估第3组和第4组中红玛咖水提取物因煮沸时间（2小时或3小时）不同而产生的差异。红玛咖提取物含有0.1毫克苄基葡萄糖苷。此后，评估红玛咖提取物中不同剂量苄基葡萄糖苷（0.02 - 0.08毫克）的剂量反应效应。