Nakahigashi Kyoko, Ishida Yuya, Matsumura Yumi, Kore-Eda Satoshi, Ohmori Katsuyuki, Fujimoto Masakazu, Yamashita Kyoko, Kotani Hirokazu, Sakurai Takaaki, Miyachi Yoshiki
Department of Dermatology, Kyoto University Hospital, Kyoto, Japan.
J Dermatol. 2008 May;35(5):283-8. doi: 10.1111/j.1346-8138.2008.00467.x.
A 57-year-old Japanese man with tumor-stage mycosis fungoides suddenly presented multiple small papules on the right chest. Histopathology of a biopsy specimen from the papules revealed medium-to-large pleomorphic lymphoid cells throughout the entire dermis but not in the epidermis, and the large cells expressed CD30 antigen. These newly-developed papules underwent spontaneous remission in the following 3 months. We reviewed the reported cases of mycosis fungoides, which showed CD30-positive large cell transformation and those of CD30-positive lymphoproliferative disorders associated with mycosis fungoides.
一名57岁的日本蕈样肉芽肿肿瘤期男性患者右胸部突然出现多个小丘疹。丘疹活检标本的组织病理学显示，整个真皮层有中到大的多形性淋巴细胞，但表皮中没有，且大细胞表达CD30抗原。这些新出现的丘疹在接下来的3个月内自行消退。我们回顾了已报道的蕈样肉芽肿出现CD30阳性大细胞转化的病例以及与蕈样肉芽肿相关的CD30阳性淋巴增殖性疾病的病例。
