Petronczki Mark, Lénárt Péter, Peters Jan-Michael
Cell Division and Aneuploidy Laboratory, Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, Hertfordshire, EN6 3LD, United Kingdom.
Dev Cell. 2008 May;14(5):646-59. doi: 10.1016/j.devcel.2008.04.014.
Polo-like kinase 1 (Plk1) is a key regulator of cell division in eukaryotic cells. New techniques, including the application of small-molecule inhibitors, have greatly expanded our knowledge of the functions, targets, and regulation of this key mitotic enzyme. In this review, we focus on how Plk1 is recruited to centrosomes, kinetochores, and the spindle midzone and what the specific tasks of Plk1 at these distinct subcellular structures might be. In particular, we highlight new work on the role of Plk1 in cytokinesis in human cells. Finally, we describe how better understanding of Plk1 functions allows critical evaluation of Plk1 as a potential drug target for cancer therapy.
Polo样激酶1（Plk1）是真核细胞中细胞分裂的关键调节因子。包括小分子抑制剂应用在内的新技术，极大地扩展了我们对这种关键有丝分裂酶的功能、靶点和调控的认识。在本综述中，我们重点关注Plk1如何被招募到中心体、动粒和纺锤体中间区，以及Plk1在这些不同亚细胞结构上的具体任务可能是什么。特别是，我们强调了Plk1在人类细胞胞质分裂中作用的新研究。最后，我们描述了对Plk1功能的更好理解如何有助于对Plk1作为癌症治疗潜在药物靶点进行关键评估。
