• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

嵌合（α-氨基酸 + 核苷-β-氨基酸）n肽寡聚体表现出序列特异性的DNA/RNA识别。

Chimeric (alpha-amino acid + nucleoside-beta-amino acid)n peptide oligomers show sequence specific DNA/RNA recognition.

作者信息

Gogoi Khirud, Kumar Vaijayanti A

机构信息

Division of Organic Chemistry, National Chemical Laboratory, Pune, 411008, India.

出版信息

Chem Commun (Camb). 2008 Feb 14(6):706-8. doi: 10.1039/b716835g.

DOI:10.1039/b716835g
PMID:18478697
Abstract

An alpha/beta-peptide backbone oligonucleotide comprising natural alpha-amino acids alternating with a beta-amino acid component derived from thymidine sequence specifically recognizes and binds to deoxy- and ribo-oligoadenylates in triplex mode.

摘要

一种由天然α-氨基酸与源自胸腺嘧啶序列的β-氨基酸组分交替构成的α/β-肽主链寡核苷酸，以三链体模式特异性识别并结合脱氧寡腺苷酸和核糖寡腺苷酸。

相似文献

1
Chimeric (alpha-amino acid + nucleoside-beta-amino acid)n peptide oligomers show sequence specific DNA/RNA recognition.嵌合（α-氨基酸 + 核苷-β-氨基酸）n肽寡聚体表现出序列特异性的DNA/RNA识别。
Chem Commun (Camb). 2008 Feb 14(6):706-8. doi: 10.1039/b716835g.
2
Glycine-Linked Nucleoside-β-Amino Acids: Polyamide Analogues of Nucleic Acids.
Bioconjug Chem. 2015 Aug 19;26(8):1737-42. doi: 10.1021/acs.bioconjchem.5b00296. Epub 2015 Jun 30.
3
Foldamers derived from nucleoside beta-amino acids: PNA Or DNA? Can we have both in one place?
Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):611-4. doi: 10.1080/15257770701490399.
4
Novel helical foldamers: organized heterogeneous backbone folding in 1 : 1 alpha/nucleoside-derived-beta-amino acid sequences.新型螺旋折叠物：1:1α/核苷衍生β-氨基酸序列中组织的杂化主链折叠。
Chem Commun (Camb). 2010 Oct 7;46(37):6962-4. doi: 10.1039/c0cc01724h. Epub 2010 Aug 23.
5
Peptides derived from nucleoside beta-amino acids form an unusual 8-helix.源自核苷β-氨基酸的肽形成一种不寻常的8-螺旋结构。
Chem Commun (Camb). 2008 Feb 7(5):585-7. doi: 10.1039/b714350h. Epub 2007 Nov 15.
6
Towards fluorous-phase synthesis of nucleoside beta-peptides.
Nucleic Acids Symp Ser (Oxf). 2008(52):337-8. doi: 10.1093/nass/nrn170.
7
Construction of peptides with nucleobase amino acids: design and synthesis of the nucleobase-conjugated peptides derived from HIV-1 Rev and their binding properties to HIV-1 RRE RNA.含核碱基氨基酸的肽的构建：源自HIV-1 Rev的核碱基共轭肽的设计与合成及其与HIV-1 RRE RNA的结合特性
Bioorg Med Chem. 2001 Apr;9(4):991-1000. doi: 10.1016/s0968-0896(00)00324-2.
8
Conformationally locked nucleosides. Synthesis of oligodeoxynucleotides containing 3'-amino-3'-deoxy-3'-N,5'(R)-C-ethylenethymidine.构象锁定核苷。含3'-氨基-3'-脱氧-3'-N,5'(R)-C-亚乙基胸苷的寡脱氧核苷酸的合成。
Nucleosides Nucleotides Nucleic Acids. 2000 Sep;19(9):1413-25. doi: 10.1080/15257770008033851.
9
Iso-thioacetamido nucleic acids (isoTANA): synthesis and DNA binding studies of lyxo/ribo oligonucleotides.异硫代乙酰氨基核酸（isoTANA）：lyxo/核糖寡核苷酸的合成及与DNA结合研究
Nucleic Acids Symp Ser (Oxf). 2008(52):145-6. doi: 10.1093/nass/nrn074.
10
Molecular dynamics and crystallization phenomenon of supercooled and glassy DNA and RNA nucleosides: β-adenosine, β-thymidine, and β-uridine.
Phys Rev E Stat Nonlin Soft Matter Phys. 2011 Nov;84(5 Pt 1):051507. doi: 10.1103/PhysRevE.84.051507. Epub 2011 Nov 23.

引用本文的文献

1
Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications.构象受限肽核酸（PNA）的展望：对结构设计、性质及应用的见解
RSC Chem Biol. 2022 Mar 18;3(6):648-697. doi: 10.1039/d2cb00017b. eCollection 2022 Jun 8.
2
Pyrrolidinyl peptide nucleic acid with α/β-peptide backbone: A conformationally constrained PNA with unusual hybridization properties.具有α/β-肽主链的吡咯烷基肽核酸：一种具有异常杂交特性的构象受限肽核酸。
Artif DNA PNA XNA. 2011 Apr;2(2):50-59. doi: 10.4161/adna.2.2.16340.
3
Differentiation of positional isomers of hybrid peptides containing repeats of β-nucleoside derived amino acid (β-Nda-) and L-amino acids by positive and negative ion electrospray ionization tandem mass spectrometry (ESI-MSn).
通过正、负离子电喷雾串联质谱（ESI-MS/MSn）对含有β-核苷衍生氨基酸（β-Nda-）和 L-氨基酸重复序列的杂肽的位置异构体进行区分。
J Am Soc Mass Spectrom. 2011 Apr;22(4):703-17. doi: 10.1007/s13361-010-0070-z. Epub 2011 Feb 8.