Murakata K, Sato A, Yoshiya M, Kim S, Watarai M, Omata Y, Furuoka H
Department of Pathobiological Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan.
J Comp Pathol. 2008 Jul;139(1):8-15. doi: 10.1016/j.jcpa.2008.03.001. Epub 2008 May 13.
This report describes intestinal lesions in five strains of mice infected orally with Lawsonia intracellularis-infected tissue homogenates from rabbits or pigs (RLI and PLI). BALB/cA, C3H/HeJ, C57BL/6J and ICR mice were susceptible to infection with RLI, whereas only C3H/HeJ, C57BL/6J and ICR strains were susceptible to PLI. In susceptible mice, crypt epithelial hyperplasia occurred in association with an inflammatory reaction, as in proliferative enteropathy (PE) in other species. The intestinal changes in the infected mice varied from mild to severe. Unlike rabbit or porcine PE, in which the changes are confined to the ileum, the lesions in mice were located in the caecum. Immunolabelling of L. intracellularis antigen was abundant in early infection when the epithelial hyperplasia was mild or absent. When the hyperplasia had become severe, however, immunolabelling was weak. For this reason, it is suggested that transitory infection of the epithelium induces epithelial hyperplasia. Genetic differences between mouse strains appeared to play an important role in the response to L. intracellularis infection. Moreover, the susceptibility of BALB/cA mice to RLI but not to PLI suggests that there are significant biological differences between L. intracellularis isolates from rabbit PE and porcine PE.
本报告描述了五株小鼠经口服感染来自兔子或猪的胞内劳森菌感染组织匀浆（RLI和PLI）后的肠道病变情况。BALB/cA、C3H/HeJ、C57BL/6J和ICR小鼠对RLI感染敏感，而只有C3H/HeJ、C57BL/6J和ICR品系对PLI敏感。在易感小鼠中，隐窝上皮增生与炎症反应相关，如同其他物种的增生性肠炎（PE）。感染小鼠的肠道变化从轻度到重度不等。与兔子或猪的PE不同，后者的变化局限于回肠，而小鼠的病变位于盲肠。在早期感染且上皮增生轻微或无增生时，胞内劳森菌抗原的免疫标记丰富。然而，当增生变得严重时，免疫标记则较弱。因此，提示上皮的短暂感染会诱导上皮增生。小鼠品系之间的遗传差异似乎在对胞内劳森菌感染的反应中起重要作用。此外，BALB/cA小鼠对RLI敏感但对PLI不敏感，这表明来自兔子PE和猪PE的胞内劳森菌分离株之间存在显著的生物学差异。
