具有MT3基序的卷尺蛋白促进噬菌体进入结核分枝杆菌的稳定期细胞。
Tape measure protein having MT3 motif facilitates phage entry into stationary phase cells of Mycobacterium tuberculosis.
作者信息
Dusthackeer Azger, Hassan V N Sameer, Kumar Vanaja
机构信息
Department of Bacteriology, Tuberculosis Research centre, Chennai 31, India.
出版信息
Comput Biol Chem. 2008 Oct;32(5):367-9. doi: 10.1016/j.compbiolchem.2008.03.016. Epub 2008 Apr 8.
Tape measure protein (TMP) having MT3 motif in mycobacteriophage TM4 genome has been reported to enable the phage infection of Mycobacterium smegmatis during stationary phase. In the present work looking at eight additional mycobacteriophage genomes by in silico analysis, six of them have been found to possess MT3 motif in TMP. The absence of MT3 motif in Che12 and D29 probably makes them incapable of infecting stationary phase cells of Mycobacterium tuberculosis which was experimentally evaluated by the performance of respective luciferase reporter phage constructs developed from the parental phages Che12, D29 and TM4.
据报道，分枝杆菌噬菌体TM4基因组中具有MT3基序的卷尺蛋白（TMP）能使噬菌体在稳定期感染耻垢分枝杆菌。在目前这项通过计算机分析研究另外八个分枝杆菌噬菌体基因组的工作中，发现其中六个在TMP中具有MT3基序。Che12和D29中缺乏MT3基序可能使它们无法感染结核分枝杆菌的稳定期细胞，这一点通过分别从亲本噬菌体Che12、D29和TM4构建的荧光素酶报告噬菌体的实验性能进行了评估。
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