Ford M E, Sarkis G J, Belanger A E, Hendrix R W, Hatfull G F
Pittsburgh Bacteriophage Institute, University of Pittsburgh, PA 15260, USA.
J Mol Biol. 1998 May 29;279(1):143-64. doi: 10.1006/jmbi.1997.1610.
Mycobacteriophage D29 is a lytic phage that infects both fast and slow-growing mycobacterial species. The complete genome sequence of D29 reveals that it is a close relative of the temperate mycobacteriophage L5, whose sequence has been described previously. The overall organization of the D29 genome is similar to that of L5, although a 3.6 kb deletion removing the repressor gene accounts for the inability of D29 to form lysogens. Comparison of the two genomes shows that they are punctuated by a large number of insertions, deletions, and substitutions of genes, consistent with the genetic mosaicism of lambdoid phages.
分枝杆菌噬菌体D29是一种能感染快速生长和缓慢生长分枝杆菌物种的裂解性噬菌体。D29的完整基因组序列显示，它是温和分枝杆菌噬菌体L5的近亲，L5的序列此前已有描述。D29基因组的总体结构与L5相似，尽管一个3.6 kb的缺失去除了阻遏基因，这导致D29无法形成溶原菌。对这两个基因组的比较表明，它们被大量的基因插入、缺失和替换所间断，这与λ样噬菌体的基因镶嵌性一致。
