Li Shiyong, Lee Andrew K
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
Int J Clin Exp Pathol. 2009 Oct 15;3(1):117-27.
The safety of silicone-based implant for mammoplasty has been debated for decades. A series of anecdotal case reports and a recent epidemiological case-control study have suggested a possible association between silicone implant and the development of primary breast ALK1-negative anaplastic large cell lymphoma (ALCL), a rare type of peripheral T-cell lymphoma. In this report, we describe an additional case of primary breast ALK1-negative ALCL in the fibrous capsule and cystic fluid of silicone breast implant in a 58 year old woman who underwent breast reconstructive surgery after lumpectomy for her infiltrating breast adenocarcinoma. Morphologically and immunohistochemically, the lymphoma cells may be confused with recurrent infiltrating breast adenocarcinoma or other non-hematolymphoid malignancies. Molecular studies were needed to determine T-lineage differentiation of the malignant lymphoma cells. We will also review the case reports and case series published in the English literature and discuss our current understanding of silicone implant in primary breast ALK1-negative ALCL.
几十年来，用于乳房整形的硅基植入物的安全性一直存在争议。一系列轶事性病例报告以及最近一项流行病学病例对照研究表明，硅酮植入物与原发性乳腺ALK1阴性间变性大细胞淋巴瘤（ALCL，一种罕见的外周T细胞淋巴瘤）的发生之间可能存在关联。在本报告中，我们描述了一名58岁女性的另一例原发性乳腺ALK1阴性ALCL病例，该病例发生在硅胶乳房植入物的纤维囊和囊液中，该女性因浸润性乳腺腺癌接受肿块切除术后进行了乳房重建手术。在形态学和免疫组织化学上，淋巴瘤细胞可能会与复发性浸润性乳腺腺癌或其他非血液淋巴系统恶性肿瘤混淆。需要进行分子研究以确定恶性淋巴瘤细胞的T细胞系分化。我们还将回顾英文文献中发表的病例报告和病例系列，并讨论我们目前对原发性乳腺ALK1阴性ALCL中硅酮植入物的理解。
