从花椒种子中分离出的新型多不饱和脂肪酸酰胺。

New polyunsaturated fatty acid amides isolated from the seeds of Zanthoxylum piperitum.

作者信息

Jang Kyoung Hwa, Chang Yong Ha, Kim Dae-Duk, Oh Ki-Bong, Oh Uhtaek, Shin Jongheon

机构信息

College of Pharmacy, Seoul National University, Seoul, 110-460, Korea.

出版信息

Arch Pharm Res. 2008 May;31(5):569-72. doi: 10.1007/s12272-001-1194-5. Epub 2008 May 15.

DOI:10.1007/s12272-001-1194-5

PMID:18481010

Abstract

Five linear fatty acid amides (1-5) of the sandshool class, including two new compounds, were isolated from Zanthoxylum piperitum seeds. Based on combined spectral analyses, the structures of new compounds 4 and 5 were determined to be 2',3'-dihydroxy-alpha-sanshool and 2',3'-dihydroxy-beta-sanshool, respectively. These compounds exhibited weak cytotoxicity in the A-549 (human lung cancer) cell line.

摘要

从花椒籽中分离出了五种山椒醇类线性脂肪酸酰胺（1-5），其中包括两种新化合物。基于综合光谱分析，确定新化合物4和5的结构分别为2'，3'-二羟基-α-山椒醇和2'，3'-二羟基-β-山椒醇。这些化合物在A-549（人肺癌）细胞系中表现出较弱的细胞毒性。