Ditzen A, Ehricht R, Monecke S
Department of Medicine III, University Hospital of Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Eur J Clin Microbiol Infect Dis. 2008 Oct;27(10):1013-5. doi: 10.1007/s10096-008-0533-3. Epub 2008 May 15.
Staphylococcus aureus is an important pathogen in injecting drug users. We illustrate this with a case of a young female patient who was admitted with multiple cutaneous and pulmonary abscesses. The causative strain was characterised using diagnostic microarrays. Genes encoding Panton-Valentine leucocidin (PVL) were detected, mecA was absent. The overall hybridisation profile allowed us to assign this isolate to ST152, being related to an epidemic community-acquired methicillin-resistant S. aureus (caMRSA) strain from south-eastern Europe. While PVL-positive MRSA has frequently been observed in injecting drug users, methicillin-susceptible isolates are usually not screened for the presence of PVL genes. The use of diagnostic microarrays contributes to patient care by the simultaneous detection of resistance and virulence markers. It also facilitates the study of phylogenetic relationships of epidemic strains.
金黄色葡萄球菌是注射吸毒者中的一种重要病原体。我们通过一名年轻女性患者的病例来说明这一点，该患者因多发性皮肤和肺部脓肿入院。使用诊断微阵列对致病菌株进行了鉴定。检测到编码杀白细胞素（PVL）的基因，未检测到mecA基因。整体杂交图谱使我们能够将该分离株归为ST152，它与来自东南欧的一种流行的社区获得性耐甲氧西林金黄色葡萄球菌（caMRSA）菌株相关。虽然在注射吸毒者中经常观察到PVL阳性的耐甲氧西林金黄色葡萄球菌，但通常不对甲氧西林敏感的分离株进行PVL基因筛查。诊断微阵列的使用通过同时检测耐药性和毒力标记物，有助于患者护理。它还便于研究流行菌株的系统发育关系。
