Samani N J, Swales J D
Department of Medicine, University of Leicester, UK.
Blood Vessels. 1991;28(1-3):210-6. doi: 10.1159/000158864.
Considerable evidence has been accumulated for a renin-angiotensin system in the blood vessel wall with local generation of both angiotensin I and angiotensin II that plays an important role in blood pressure regulation. A major source for vascular renin is renal renin taken up by the arterial wall from the circulation. However, recent studies suggest that, in addition, local synthesis of components of the renin-angiotensin cascade also takes place in the vessel wall. The contribution that these locally derived components make to the functions of the vascular renin-angiotensin system remains to be elucidated. Studies, particularly in vitro, suggest that vascular pathways for angiotensin generation not involving renin or angiotensin-converting enzyme may also exist. As in the case of the locally derived components of the renin-angiotensin cascade, the role of these alternate pathways in the physiology of the vascular wall remain to be defined.
血管壁中肾素-血管紧张素系统的相关证据已大量积累，血管壁可局部生成血管紧张素I和血管紧张素II，这在血压调节中发挥重要作用。血管肾素的一个主要来源是动脉壁从循环中摄取的肾素。然而，最近的研究表明，除此之外，血管壁中也会发生肾素-血管紧张素级联反应各成分的局部合成。这些局部产生的成分对血管肾素-血管紧张素系统功能的贡献仍有待阐明。特别是体外研究表明，可能还存在不涉及肾素或血管紧张素转换酶的血管紧张素生成途径。与肾素-血管紧张素级联反应的局部产生成分一样，这些替代途径在血管壁生理学中的作用仍有待确定。
