Dzau V J
Molecular and Cellular, Vascular Research Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
J Hypertens. 1989 Dec;7(12):933-6. doi: 10.1097/00004872-198912000-00001.
In summary, multiple pathways of angiotensin production may exist in the blood vessel wall (Fig. 1), in addition to the well described renin--ACE enzymatic axis. It is not known whether these enzymatic pathways represent in vitro phenomena, or authentic in vivo alternate pathways which are activated only when the renin--ACE pathway is blocked, or whether they are operative at all times in the vessel wall. If these multiple pathways are functional, then the vascular angiotensin system may be very complicated, and may vary in different pathophysiological states. Future research in this area is likely to yield important and novel information on the in vivo pathways of production and function of vascular angiotensin.
总之，除了广为人知的肾素 - 血管紧张素转换酶（ACE）酶促轴外，血管壁中可能存在多种血管紧张素生成途径（图1）。目前尚不清楚这些酶促途径是体外现象，还是仅在肾素 - ACE途径受阻时才被激活的真正体内替代途径，亦或是它们在血管壁中一直都起作用。如果这些多种途径起作用，那么血管紧张素系统可能非常复杂，并且在不同的病理生理状态下可能有所不同。该领域的未来研究可能会产生关于血管紧张素在体内生成途径和功能的重要且新颖的信息。
