Agbor Terence A, Taylor Cormac T
School of Medicine and Medical Science and UCD Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland.
Biochem Soc Trans. 2008 Jun;36(Pt 3):445-8. doi: 10.1042/BST0360445.
Post-translational modification is a critical event in the dynamic regulation of protein stability, location, structure, function, activity and interaction with other proteins and as such plays an important role in organism complexity. Over the last 10 years, the extensive and critical role of one such protein modification by SUMO (small ubiquitin-related modifier) has become apparent. The focus of this mini-review will be on recent reports of a possible functional role for the SUMO pathway in the adaptive cellular response to metabolic challenge, such as oxygen deprivation (hypoxia). Here, we will briefly review the evolving evidence for this pathway in the regulation of a number of metabolic regulators and discuss a possible role for SUMOylation in the regulation of basic metabolic function.
翻译后修饰是蛋白质稳定性、定位、结构、功能、活性以及与其他蛋白质相互作用的动态调节中的关键事件，因此在生物体复杂性中发挥着重要作用。在过去10年中，一种由SUMO（小泛素相关修饰物）介导的蛋白质修饰的广泛且关键的作用已变得明显。本小型综述的重点将是关于SUMO途径在细胞对代谢挑战（如缺氧）的适应性反应中可能发挥的功能作用的最新报道。在这里，我们将简要回顾该途径在调节多种代谢调节因子方面不断发展的证据，并讨论SUMO化在基础代谢功能调节中的可能作用。
