Palese Alvisa, Lamanna Francesca, Di Monte Carmen, Calligaris Sonia, Doretto Mara, Criveller Michela
School of Nursing, University of Udine, Udine, Italy.
J Clin Nurs. 2008 Jun;17(11):1403-10. doi: 10.1111/j.1365-2702.2007.02182.x.
To determine if patients with left- or right-sided hemisphere neoplasm perceive their quality of life (QoL) differently.
It is not clear whether patients with a lesion in the left hemisphere have a different QoL than those with a lesion in the right hemisphere. (1) In the pre-operative period, patients with a left-sided lesion may have different symptoms according to the position of the tumour. (2) Studies on patients with brain injury demonstrate an association between left frontal lesions and depression: depression can alter the patients' perception of QoL. (3) In the postoperative period, right-handed patients may be disadvantaged by surgical trauma to the motor cortex in the left hemisphere. (4) During the different phases of the disease, the various functions of the two hemispheres may influence the patient's capacity to control QoL; also, as suggested by authors, both the ego and the conscience are mostly located in the left hemisphere. This is the reason that patients with a left-sided lesion may perceive a worse QoL.
A review of literature was carried out using the Medline database (1966-2007) and CINHAL (1982-2007), using the following Mesh Terms and key words: brain neoplasm, tumour or cancer, hemispheric dominance or laterality or right or left hemisphere, QoL.
Seven studies emerged that documented non-homogeneous results and which included different populations. The association between QoL and the side of the lesion was evaluated.
The lack of a substantial number of recent, robust follow-up studies investigating the QoL in patients at different stages of disease and treatment indicates that more research is needed. Relevance to clinical practice. Understanding the QoL in patients with brain neoplasm and the differences between right and left hemisphere sites of the neoplasm can help nurses develop different interventions and offer more guidance for effective clinical intervention.
确定左侧或右侧半球肿瘤患者对其生活质量（QoL）的感知是否存在差异。
尚不清楚左侧半球有病变的患者与右侧半球有病变的患者的生活质量是否不同。（1）在术前阶段，左侧病变患者可能因肿瘤位置不同而有不同症状。（2）对脑损伤患者的研究表明，左侧额叶病变与抑郁症之间存在关联：抑郁症会改变患者对生活质量的感知。（3）在术后阶段，右利手患者可能因左半球运动皮层的手术创伤而处于不利地位。（4）在疾病的不同阶段，两个半球的各种功能可能会影响患者控制生活质量的能力；此外，正如作者所指出的，自我和良知大多位于左侧半球。这就是左侧病变患者可能感觉生活质量较差的原因。
使用Medline数据库（1966 - 2007年）和CINHAL（1982 - 2007年）进行文献综述，使用以下医学主题词和关键词：脑肿瘤、肿瘤或癌症、半球优势或偏侧性或右或左半球、生活质量。
出现了七项研究，记录了非同质的结果，且研究对象不同。评估了生活质量与病变侧之间的关联。
缺乏大量近期的、有力的随访研究来调查疾病和治疗不同阶段患者的生活质量，这表明需要更多研究。与临床实践的相关性。了解脑肿瘤患者的生活质量以及肿瘤在右半球和左半球部位的差异，有助于护士制定不同的干预措施，并为有效的临床干预提供更多指导。
