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肾移植后霉菌性假性动脉瘤:一例病例报告及文献复习

Mycotic pseudoaneurysm following a kidney transplant: a case report and review of the literature.

作者信息

Osmán Ignacio, Barrero Rafael, León Eduardo, Medina Rafael, Torrubia Francisco

机构信息

Urology, Hospitales Universitarios Virgen del Rocio, Av. Manuel Siurot S/N, Spain.

出版信息

Pediatr Transplant. 2009 Aug;13(5):615-9. doi: 10.1111/j.1399-3046.2008.00971.x. Epub 2008 May 11.

Abstract

Vascular complications represent a significant cause of morbidity and mortality following a kidney transplant. Pseudoaneurysms are rare, occurring in approximately 1% of cases. We present a 15-yr-old patient who received a kidney transplant in the right iliac fossa. Thirty-six days following the transplant, the patient was admitted to the hospital because of a marked increase in serum creatinine levels, arterial hypertension, scrotal edema, and lower right limb pain. The patient did not present fever or raised inflammatory markers. A pseudoaneurysm was diagnosed by means of a Doppler echography and a CT. By a selective arteriography of the right iliac artery, we placed a 8 x 5 cm stent to isolate the pseudoaneurysm, due to the high risk of an extensive defect occurring in the arterial wall. Forty-eight h later the patient underwent transplant nephrectomy. Seven days following surgery, the patient experienced febrile syndrome and therefore another CT was carried out which showed a large abscess around the stent. So we decided to perform another intervention in order to drain this abscess. Due to the extensive loss of the arterial wall where the prosthesis was largely exposed, we ligated the common iliac and external iliac arteries, removed the prosthesis and performed a femoro-femoral bypass with the usual subcutaneous positioning of the prosthesis (separate from surgical site). The stent and mural thrombus were sent for culture analysis and Candida albicans was observed. The diagnosis of a pseudoaneurysm in these types of patients continues to be considered as a surgical emergency by the majority of authors. Transplantectomy is the most frequently used treatment technique. Positioning a stent prior to transplantectomy avoids ligature of the iliac artery in the majority of cases.

摘要

血管并发症是肾移植后发病和死亡的重要原因。假性动脉瘤较为罕见,发生率约为1%。我们报告一名15岁的患者,其右髂窝接受了肾移植。移植后36天,患者因血清肌酐水平显著升高、动脉高血压、阴囊水肿和右下肢疼痛入院。患者未出现发热或炎症标志物升高。通过多普勒超声和CT诊断为假性动脉瘤。由于动脉壁发生广泛缺损的风险较高,我们通过右髂动脉选择性动脉造影放置了一个8×5 cm的支架来隔离假性动脉瘤。48小时后,患者接受了移植肾切除术。术后7天,患者出现发热综合征,因此再次进行CT检查,结果显示支架周围有一个大脓肿。于是我们决定再次进行干预以引流该脓肿。由于假体大部分暴露处动脉壁广泛缺损,我们结扎了髂总动脉和髂外动脉,取出假体,并进行了股-股旁路手术,假体通常置于皮下(与手术部位分开)。将支架和壁血栓送去进行培养分析,观察到白色念珠菌。大多数作者仍将这类患者的假性动脉瘤诊断视为外科急症。移植肾切除术是最常用的治疗技术。在移植肾切除术之前放置支架可避免在大多数情况下结扎髂动脉。

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