Meyer Cari, Cambray Rachel
University of Wisconsin School of Medicine and Public Health, Clinical Science Center, Madison, WI 53792-3272, USA.
Paediatr Anaesth. 2008 Sep;18(9):888-90. doi: 10.1111/j.1460-9592.2008.02583.x. Epub 2008 May 12.
We report three sequential cases in which children received 100 times the intended dose of clonidine in their single shot caudals. Although all experienced excessive somnolence for up to 24 h, none had respiratory depression, oxygen desaturation, supplemental oxygen requirement, or hemodynamic instability. These cases suggest a large margin of safety exists for caudally administered clonidine in healthy children.
我们报告了三例连续的病例，这些儿童在单次骶管阻滞中接受了预期剂量100倍的可乐定。尽管所有人都经历了长达24小时的过度嗜睡，但没有人出现呼吸抑制、氧饱和度下降、需要补充氧气或血流动力学不稳定的情况。这些病例表明，在健康儿童中，骶管注射可乐定存在很大的安全 margin 。 （注：这里margin结合语境推测是“余地、幅度”之类的意思，但按照要求未加解释）
