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小儿可乐定——一篇综述

Clonidine in paediatrics - a review.

作者信息

Basker Sujatha, Singh Georgene, Jacob Rebecca

机构信息

Asst. Professor, Department of Anaesthesiology and Critical Care, Christian Medical College, Vellore, Tamil Nadu. 632004.

出版信息

Indian J Anaesth. 2009 Jun;53(3):270-80.

PMID:20640134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2900117/
Abstract

Clonidine, an alpha-2 agonist is a known antihypertensive agent. Because of its sedative and analgesic effects, it is gaining popularity in anaesthesiology. It can be used to premedicate children, as an adjuvant to regional and general anaesthesia and it has several other applications in paediatric anaesthesia. It has also found use in the paediatric intensive care as a sedative, analgesic and to ensure haemodynamic stability. As in the case of any other anaesthetic drug, its use has to be vigilantly monitored.

摘要

可乐定,一种α-2激动剂,是一种已知的抗高血压药物。由于其镇静和镇痛作用,它在麻醉学中越来越受欢迎。它可用于小儿术前用药,作为区域麻醉和全身麻醉的辅助药物,并且在小儿麻醉中还有其他几种应用。它还被用于儿科重症监护,作为镇静剂、镇痛药并确保血流动力学稳定。与任何其他麻醉药物一样,其使用必须受到密切监测。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f228/2900117/5219b455e9ae/IJA-53-270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f228/2900117/5219b455e9ae/IJA-53-270-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f228/2900117/5219b455e9ae/IJA-53-270-g001.jpg

相似文献

1
Clonidine in paediatrics - a review.小儿可乐定——一篇综述
Indian J Anaesth. 2009 Jun;53(3):270-80.
2
[Efficacy of clonidine in paediatric anaesthesia].可乐定在小儿麻醉中的疗效
Anasthesiol Intensivmed Notfallmed Schmerzther. 2005 Oct;40(10):567-75. doi: 10.1055/s-2005-870158.
3
Clonidine in paediatric anaesthesia.可乐定在小儿麻醉中的应用
Curr Opin Anaesthesiol. 2002 Jun;15(3):309-16. doi: 10.1097/00001503-200206000-00006.
4
[The role of clonidine in anesthesia].
Anaesthesist. 1993 Mar;42(3):131-41.
5
Clonidine--a potent analgesic adjuvant.可乐定——一种强效镇痛辅助剂。
Curr Opin Anaesthesiol. 2002 Oct;15(5):511-7. doi: 10.1097/00001503-200210000-00007.
6
The efficacy of clonidine for reducing perioperative haemodynamic changes and volatile anaesthetic requirements in children.可乐定在减少儿童围手术期血流动力学变化及挥发性麻醉药需求方面的疗效。
Acta Anaesthesiol Scand. 1996 Jul;40(6):746-51. doi: 10.1111/j.1399-6576.1996.tb04522.x.
7
Effect of addition of clonidine to local anaesthetic mixture for peribulbar block.可乐定添加至局部麻醉混合液用于球周阻滞的效果。
Anaesth Intensive Care. 2002 Aug;30(4):438-41. doi: 10.1177/0310057X0203000406.
8
[Comparison of premedication with clonidine and midazolam combined with TCI for orthopaedic shoulder surgery].可乐定与咪达唑仑联合靶控输注用于骨科肩部手术术前用药的比较
Anasthesiol Intensivmed Notfallmed Schmerzther. 2003 Dec;38(12):772-80. doi: 10.1055/s-2003-45396.
9
Caudal ropivacaine-clonidine: A better post-operative analgesic approach.尾端罗哌卡因-可乐定:一种更好的术后镇痛方法。
Indian J Anaesth. 2010 May;54(3):226-30. doi: 10.4103/0019-5049.65368.
10
The potentiation of halothane anaesthesia by clonidine.可乐定对氟烷麻醉的增强作用。
Acta Anaesthesiol Scand. 1979 Feb;23(1):107-11. doi: 10.1111/j.1399-6576.1979.tb01429.x.

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Sedation Methods in Paediatric Auditory Electrophysiologic Testing: A Narrative Review.儿科听觉电生理测试中的镇静方法:叙述性综述
Audiol Res. 2025 Jul 4;15(4):82. doi: 10.3390/audiolres15040082.
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Sedation and Pain Management in Neonates Undergoing Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy.新生儿缺氧缺血性脑病治疗性低温期间的镇静与疼痛管理
Children (Basel). 2025 Feb 19;12(2):253. doi: 10.3390/children12020253.
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Comparison of the Efficacies of Dexmedetomidine and Clonidine in Preventing Postoperative Nausea and Vomiting in Paediatric Patients Undergoing Abdominal Surgeries.

本文引用的文献

1
One hundred times the intended dose of caudal clonidine in three pediatric patients.三名儿科患者尾侧给予可乐定的剂量达预期剂量的100倍。
Paediatr Anaesth. 2008 Sep;18(9):888-90. doi: 10.1111/j.1460-9592.2008.02583.x. Epub 2008 May 12.
2
Intravenous clonidine infusion in infants after cardiovascular surgery.心血管手术后婴儿静脉输注可乐定
Paediatr Anaesth. 2008 Mar;18(3):217-22. doi: 10.1111/j.1460-9592.2008.02413.x.
3
Safety and efficacy of patient controlled epidural analgesia following pediatric spinal surgery.小儿脊柱手术后患者自控硬膜外镇痛的安全性与有效性
右美托咪定与可乐定预防小儿腹部手术术后恶心呕吐效果的比较
Cureus. 2024 Jul 18;16(7):e64789. doi: 10.7759/cureus.64789. eCollection 2024 Jul.
4
Guidelines for treatment of acute pain in children - the consensus statement of the Section of Paediatric Anaesthesiology and Intensive Therapy of the Polish Society of Anaesthesiology and Intensive Therapy.儿童急性疼痛治疗指南 - 波兰麻醉学和重症治疗学会儿科麻醉学和重症治疗科的共识声明。
Anaesthesiol Intensive Ther. 2022;54(3):197-218. doi: 10.5114/ait.2022.118972.
5
Pre-formulation and Stability Study of 20-mcg Clonidine Hydrochloride Pediatric Capsules.20微克盐酸可乐定儿科胶囊的处方前研究与稳定性研究
J Pediatr Pharmacol Ther. 2022;27(7):625-631. doi: 10.5863/1551-6776-27.7.625. Epub 2022 Sep 26.
6
Continuous clonidine infusion: an alternative for children on mechanical ventilation.持续可乐定输注:机械通气患儿的另一种选择。
Rev Assoc Med Bras (1992). 2022 Jul;68(7):xxx. doi: 10.1590/1806-9282.20220166.
7
Stability evaluation of compounded clonidine hydrochloride oral liquids based on a solid-phase extraction HPLC-UV method.基于固相萃取 HPLC-UV 法的复方盐酸可乐定口服液的稳定性评价。
PLoS One. 2021 Nov 30;16(11):e0260279. doi: 10.1371/journal.pone.0260279. eCollection 2021.
8
Clonidine for sedation in infants during therapeutic hypothermia with neonatal encephalopathy: pilot study.氯胺酮在新生儿脑病亚低温治疗中镇静:初步研究。
J Perinatol. 2022 Mar;42(3):319-327. doi: 10.1038/s41372-021-01151-1. Epub 2021 Sep 16.
9
A Comparative Evaluation of Oral Clonidine, Dexmedetomidine, and Melatonin As Premedicants in Pediatric Patients Undergoing Subumbilical Surgeries.口服可乐定、右美托咪定和褪黑素作为脐下手术小儿患者术前用药的比较评价
Rom J Anaesth Intensive Care. 2020 Jul;27(1):35-42. doi: 10.2478/rjaic-2020-0006. Epub 2020 Aug 10.
10
Current State of Analgesia and Sedation in the Pediatric Intensive Care Unit.儿科重症监护病房镇痛与镇静的现状
J Clin Med. 2021 Apr 23;10(9):1847. doi: 10.3390/jcm10091847.
Paediatr Anaesth. 2008 Feb;18(2):132-9. doi: 10.1111/j.1460-9592.2007.02383.x.
4
Intranasal clonidine as a premedicant: three cases with unique indications.鼻内可乐定作为术前用药:三例特殊适应症病例
Paediatr Anaesth. 2008 Jan;18(1):71-3. doi: 10.1111/j.1460-9592.2007.02349.x.
5
Premedication in children: a comparison of oral midazolam and oral clonidine.儿童术前用药:口服咪达唑仑与口服可乐定的比较。
Paediatr Anaesth. 2007 Dec;17(12):1143-9. doi: 10.1111/j.1460-9592.2007.02332.x.
6
Clonidine disposition in children; a population analysis.可乐定在儿童体内的处置;一项群体分析。
Paediatr Anaesth. 2007 Oct;17(10):924-33. doi: 10.1111/j.1460-9592.2007.02251.x.
7
Current United Kingdom sedation practice in pediatric intensive care.英国目前在儿科重症监护中的镇静实践。
Paediatr Anaesth. 2007 Jul;17(7):675-83. doi: 10.1111/j.1460-9592.2006.02180.x.
8
Effects of preanesthetic administration of midazolam, clonidine, or dexmedetomidine on postoperative pain and anxiety in children.麻醉前给予咪达唑仑、可乐定或右美托咪定对儿童术后疼痛和焦虑的影响。
Paediatr Anaesth. 2007 Jul;17(7):667-74. doi: 10.1111/j.1460-9592.2006.02185.x.
9
Cardiac arrest in a child with cerebral palsy undergoing sevoflurane induction of anesthesia after preoperative clonidine.一名患有脑瘫的儿童在术前使用可乐定后接受七氟醚麻醉诱导时发生心脏骤停。
Paediatr Anaesth. 2007 Mar;17(3):270-2. doi: 10.1111/j.1460-9592.2006.02065.x.
10
Steal-induction after clonidine premedication: a comparison of the oral and nasal route.可乐定预处理后诱发盗血:口服与鼻内途径的比较。
Paediatr Anaesth. 2007 Mar;17(3):230-4. doi: 10.1111/j.1460-9592.2006.02080.x.