Nishimura M, Takahashi H, Matsusawa M, Ikegaki I, Sakamoto M, Nakanishi T, Hirabayashi M, Yoshimura M
Department of Clinical Laboratory and Medicine, Kyoto Prefectural University of Medicine, Japan.
J Hypertens. 1991 Jan;9(1):71-6. doi: 10.1097/00004872-199101000-00011.
We investigated the effects of intracerebroventricular infusions of endothelin on cardiovascular and endocrinological responses using conscious, unrestrained rats. Chronic intracerebroventricular infusions of endothelin, 10 pmol/h for 7 days, elevated arterial pressure significantly on days 5, 6 and 7 of the infusion, compared with intracerebroventricular infusions of the vehicle. Heart rate decreased from day 1 of the infusion of endothelin until the end of the experiment. The urinary excretion of norepinephrine increased on day 3 and epinephrine increased on days 3, 4 and 5 of endothelin infusion. The urinary excretion of arginine vasopressin increased on day 5, 6 and 7 of the infusion. These findings suggest that chronic intracerebroventricular infusions of endothelin elicit elevations in arterial pressure and that the initiation of blood pressure rises can be related to sympathetic activation although the actual role for the pressor responses has been played by the released arginine vasopressin.
我们使用清醒、不受束缚的大鼠，研究了脑室内注入内皮素对心血管和内分泌反应的影响。与注入赋形剂相比，连续7天以每小时10皮摩尔的剂量慢性脑室内注入内皮素，在注入的第5、6和7天显著升高了动脉血压。从注入内皮素的第1天到实验结束，心率下降。注入内皮素的第3天，去甲肾上腺素的尿排泄量增加，第3、4和5天肾上腺素的尿排泄量增加。注入的第5、6和7天，精氨酸加压素的尿排泄量增加。这些发现表明，慢性脑室内注入内皮素会引起动脉血压升高，尽管实际的升压反应是由释放的精氨酸加压素发挥作用，但血压升高的起始可能与交感神经激活有关。
