内皮素对神经垂体神经末梢神经肽释放的调节作用。
Endothelin regulation of neuropeptide release from nerve endings of the posterior pituitary.
作者信息
Ritz M F, Stuenkel E L, Dayanithi G, Jones R, Nordmann J J
机构信息
Centre National de la Recherche Scientifique, Strasbourg, France.
出版信息
Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8371-5. doi: 10.1073/pnas.89.17.8371.
Abstract
We have investigated the role of endothelin (ET) in the stimulus-secretion coupling mechanism in the posterior pituitary. We report that isolated nerve endings contain immunoreactive endothelin, the level of which is regulated by homeostatic mechanisms involved in control of water balance. ET-1 and ET-3 potentiate vasopressin release induced by depolarization through interaction with specific receptors of the ETA subtype and this response is antagonized by sarafotoxin S6b. The second messenger for this effect, however, remains unknown since the potentiation of depolarization-induced vasopressin release occurs in the absence of an increase in cellular calcium.
摘要
我们研究了内皮素（ET）在垂体后叶刺激-分泌偶联机制中的作用。我们报告称，分离出的神经末梢含有免疫反应性内皮素，其水平受参与水平衡控制的稳态机制调节。ET-1和ET-3通过与ETA亚型的特定受体相互作用，增强去极化诱导的血管加压素释放，而这种反应可被蛙皮毒素S6b拮抗。然而，由于去极化诱导的血管加压素释放增强在细胞钙不增加的情况下发生，因此这种效应的第二信使仍然未知。
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