局部麻醉药与人体红细胞葡萄糖转运系统的相互作用。
Interaction of local anesthetics with the transport system of glucose in human erythrocytes.
作者信息
Lacko L, Wittke B, Lacko I
出版信息
J Cell Physiol. 1977 Aug;92(2):257-63. doi: 10.1002/jcp.1040920214.
PMID:18483
Abstract
Local anesthetics inhibit the exhange transport of glucose in human erythroytes. All compounds tested showed a competitive inhibition except lidocaine and baycaine causing a non-competitive one. Moreover the transport system can bind two inhibitor molecules to one transport site as described for tetracaine and oxybuprocaine.
摘要
局部麻醉药会抑制人体红细胞中葡萄糖的交换转运。除利多卡因和贝可卡因引起非竞争性抑制外，所有受试化合物均表现出竞争性抑制。此外，如丁卡因和奥布卡因所述，转运系统可在一个转运位点结合两个抑制剂分子。
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