Lacko L, Wittke B, Lacko I
J Cell Physiol. 1979 Jul;100(1):169-74. doi: 10.1002/jcp.1041000117.
The homologous compounds of the 4-alkoxy- and 4-alkylamino-series inhibit the exchange transport of glucose in human erythrocytes; they show a competitive inhibition with one or two inhibitor molecules which become bound to a singular site of the transport system for glucose. The importance of length of hydrocarbon chain of the localanesthetics for the mode of their action is discussed.
4-烷氧基和4-烷基氨基系列的同源化合物抑制人红细胞中葡萄糖的交换转运;它们表现出与一或两个抑制剂分子的竞争性抑制,这些抑制剂分子与葡萄糖转运系统的单个位点结合。讨论了局部麻醉剂烃链长度对其作用方式的重要性。