Nazer H Julio, Cifuentes O Lucía, Millán Z Francisca, Vacarisas A Paola, Köbrich Sch Stephanie, Aguila R Alfredo
Unidad de Neonatología, Hospital Clínico, Universidad de Chile, Santiago, Chile.
Rev Med Chil. 2008 Feb;136(2):201-8. Epub 2008 May 7.
The role of advanced maternal age as a risk factor for congenital malformations in offspring is known. However, the influence of paternal age is not clear.
To evaluate the association between advanced paternal age and the risk for congenital malformations.
Analysis of maternal and paternal age of cases (malformed newborns) and controls from ECLAMC Database (Latin American Collaborative Study of Congenital Malformations) registered at the University of Chile Clinical Hospital during the decade from Jan 1 1997 to Dec 31 2006. Newborns and stillborns were grouped according to maternal age into 6 intervals. In each interval, paternal ages of cases and controls were compared. The inverse procedure was performed to assess maternal age effect. Other variables as gestational age and birth weight were analyzed for the intervals of maternal and paternal ages.
No significant differences were observed in paternal age between cases and controls in any of the intervals of maternal age. However, mean maternal age was higher for cases than for controls (p =0,0149). Gestational age and birth weight depend more on being case or control than on the age of parents.
No differences in paternal age were observed between cases and controls in this series of newborns.
高龄产妇作为子代先天性畸形风险因素的作用是已知的。然而，父亲年龄的影响尚不清楚。
评估父亲高龄与先天性畸形风险之间的关联。
分析1997年1月1日至2006年12月31日这十年间在智利大学临床医院登记的来自拉丁美洲先天性畸形协作研究（ECLAMC数据库）的病例（畸形新生儿）和对照的母亲和父亲年龄。新生儿和死产儿根据母亲年龄分为6个区间。在每个区间内，比较病例组和对照组的父亲年龄。采用相反的程序评估母亲年龄的影响。对母亲和父亲年龄区间的孕周和出生体重等其他变量进行分析。
在任何母亲年龄区间内，病例组和对照组的父亲年龄均未观察到显著差异。然而，病例组的平均母亲年龄高于对照组（p = 0.0149）。孕周和出生体重更多地取决于是否为病例或对照，而非父母的年龄。
在这一系列新生儿中，病例组和对照组的父亲年龄未观察到差异。
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