Chariot P, Monnet I, LeLong F, Chleq C, Droz J P, de Cremoux H
Department of Pneumology, Centre Hospitalier Intercommunal de Créteil, France.
Am J Med. 1991 Mar;90(3):381-5.
The first known case of systemic mast cell disease associated with a germ cell tumor is reported. Six months after the complete remission of a primary mediastinal germ cell tumor treated by chemotherapy and resection, a young man had a series of episodes of hypotension and syncope and, a few months later, a gastric hemorrhage and coagulation disorder. The diagnosis of systemic mast cell disease was made in view of bone marrow and liver biopsies. A transient circulating heparin-like anticoagulant was noted. The occurrence in a short period of these two unusual conditions, given previous knowledge of hematologic disorders associated with germ cell tumors, suggests that the present association is not a coincidence. Systemic mast cell disease should be considered among the hematologic disorders associated with a germ cell tumor.
报道了首例已知的与生殖细胞肿瘤相关的系统性肥大细胞病病例。一名年轻男性在接受化疗和手术切除的原发性纵隔生殖细胞肿瘤完全缓解6个月后，出现了一系列低血压和晕厥发作，几个月后又出现胃出血和凝血障碍。鉴于骨髓和肝脏活检结果，诊断为系统性肥大细胞病。发现了一种短暂循环的类肝素抗凝物质。考虑到既往已知与生殖细胞肿瘤相关的血液系统疾病，这两种不寻常情况在短时间内出现，提示目前的关联并非巧合。在与生殖细胞肿瘤相关的血液系统疾病中应考虑系统性肥大细胞病。
