Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Avian Pathol. 1998;27(1):100-2. doi: 10.1080/03079459808419281.
Spontaneous gizzard adenocarcinoma was found in a 15-year-old male Humboldt penguin (Spheniscus humboldti). The lesser curvature of the gizzard wall was extensively and markedly thickened with a hard white tumour mass. Histopathologically, the tumour in the gizzard consisted of two structures: small to large acini lined by cuboidal or flattened cells with poor stroma in the mucosa, and undifferentiated tumour cells arranged singly or in cords with acinar structures separated by dense fibrous tissue in the muscular layer. Small white metastatic tumours of the intestine and the pancreas had a similar histological appearance to that in the muscular layer of the gizzard. From the location of tumour in the gizzard and the stainability with combined alcian blue pH 2.5-periodic acid Schiff, it was considered that this tumour might originate from the lining cells of the tip of the gizzard mucosal folds.
在一只 15 岁雄性洪堡企鹅（Spheniscus humboldti）中发现了自发性肌胃腺癌。肌胃壁的小弯侧广泛而明显增厚，有硬的白色肿瘤肿块。组织病理学上，肌胃中的肿瘤由两种结构组成：黏膜中小到大型的腺腔由立方或扁平细胞排列而成，基质较少，而在肌层中，未分化的肿瘤细胞呈单行或索状排列，与腺腔结构分离，由致密的纤维组织分隔。肠道和胰腺的白色小结节转移瘤与肌胃肌层的组织学表现相似。根据肿瘤在肌胃中的位置以及联合阿尔辛蓝 pH 2.5-过碘酸雪夫染色的染色性，认为该肿瘤可能起源于肌胃黏膜褶皱尖端的衬里细胞。
