Schmidt Volker, Philipp Hans-Christian, Thielebein Jens, Troll Susanne, Hebel Christiana, Aupperle Heike
Clinic for Birds and Reptiles, Faculty of Veterinary Medicine, University of Leipzig, Germany.
J Avian Med Surg. 2012 Jun;26(2):101-6. doi: 10.1647/2011-017.1.
Multicentric T-cell lymphomas were diagnosed in two birds from separate zoological collections: one in a 27-year-old female Humboldt penguin (Spheniscus humboldti) and the second in an adult pink-backed pelican (Pelecanus rufescens). The main clinical sign in the penguin was dysphagia caused by lymphoma formation in the esophagus. Besides the esophageal lymphoma, neoplastic lymphoid cells were observed in the adrenal glands, liver, kidneys, lung, proventriculus, and gizzard. The pelican was found dead without a clinical history. Neoplastic lymphoid cells were observed in the kidneys, liver, pancreas, spleen, ventriculus, and small intestine. Neoplastic cells of the penguin as well as of the pelican were immunoreactive to CD3 antigen, suggesting the lymphomas were of T-cell origin. In both cases, test results were negative for Marek's disease virus, avian leukosis virus, and reticuloendotheliosis virus. In the pelican, a skin melanoma was diagnosed on the left throat pouch in addition to the multicentric T-cell lymphoma.
在来自不同动物园的两只鸟类中诊断出多中心性T细胞淋巴瘤：一只是一只27岁的雌性洪堡企鹅（Spheniscus humboldti），另一只是一只成年粉红背鹈鹕（Pelecanus rufescens）。企鹅的主要临床症状是由食管淋巴瘤形成引起的吞咽困难。除了食管淋巴瘤外，在肾上腺、肝脏、肾脏、肺、腺胃和砂囊中也观察到肿瘤性淋巴细胞。这只鹈鹕被发现死亡，没有临床病史。在肾脏、肝脏、胰腺、脾脏、心室和小肠中观察到肿瘤性淋巴细胞。企鹅和鹈鹕的肿瘤细胞对CD3抗原具有免疫反应性，表明淋巴瘤起源于T细胞。在这两种情况下，马立克氏病病毒、禽白血病病毒和网状内皮组织增殖病病毒的检测结果均为阴性。在这只鹈鹕中，除了多中心性T细胞淋巴瘤外，还在左侧喉囊诊断出皮肤黑色素瘤。
