晶体诱导的中性粒细胞活化。I. 微晶对钙动员和超氧化物产生的起始作用及调节
Crystal-induced neutrophil activation. I. Initiation and modulation of calcium mobilization and superoxide production by microcrystals.
作者信息
Naccache P H, Grimard M, Roberge C J, Gilbert C, Lussier A, de Médicis R, Poubelle P E
机构信息
Départment de Médicine, Université Laval, Ste Foy, Quebec, Canada.
出版信息
Arthritis Rheum. 1991 Mar;34(3):333-42. doi: 10.1002/art.1780340311.
The effects of monosodium urate and calcium pyrophosphate dihydrate crystals on the levels of cytoplasmic free calcium and on the oxidative burst in normal human blood neutrophils were examined. The pattern of sensitivity to granulocyte-macrophage colony-stimulating factor, colchicine, cytochalasin B, pertussis toxin, diglyceride kinase, and protein kinase C inhibitors differentiated the mechanism(s) of neutrophil activation by the crystals from that involved in the responses to soluble chemotactic factors and indicated that individual crystals can use several activation pathways.
研究了尿酸单钠和二水焦磷酸钙晶体对正常人血液中性粒细胞胞质游离钙水平和氧化爆发的影响。对粒细胞-巨噬细胞集落刺激因子、秋水仙碱、细胞松弛素B、百日咳毒素、甘油二酯激酶和蛋白激酶C抑制剂的敏感性模式区分了晶体激活中性粒细胞的机制与对可溶性趋化因子反应所涉及的机制，并表明单个晶体可以使用多种激活途径。
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